May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Analysis of Electrically Evoked Cortical Potentials by Acute Suprachoroidal Electrical Stimulation of Rabbit Retina
Author Affiliations & Notes
  • H. Chung
    Ophthalmology, Seoul National University School of Medicine, Seoul, Republic of Korea
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
  • S. Woo
    Ophthalmology, Seoul National University School of Medicine, Seoul, Republic of Korea
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
  • J. Zhou
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
    School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
  • E. Kim
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
    School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
  • T. Kim
    Ophthalmology, Seoul National University School of Medicine, Seoul, Republic of Korea
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
  • J. Park
    Ophthalmology, Seoul National University School of Medicine, Seoul, Republic of Korea
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
  • J.-M. Seo
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
    School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
  • H. Yu
    Ophthalmology, Seoul National University School of Medicine, Seoul, Republic of Korea
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
  • Y. Yu
    Ophthalmology, Seoul National University School of Medicine, Seoul, Republic of Korea
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
  • S. Kim
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
    School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  H. Chung, None; S. Woo, None; J. Zhou, None; E. Kim, None; T. Kim, None; J. Park, None; J. Seo, None; H. Yu, None; Y. Yu, None; S. Kim, None.
  • Footnotes
    Support  Korea Health 21 R&D Project MOHW A050251, NBS-ERC supported by KOSEF
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1778. doi:https://doi.org/
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    • Get Citation

      H. Chung, S. Woo, J. Zhou, E. Kim, T. Kim, J. Park, J.-M. Seo, H. Yu, Y. Yu, S. Kim; Analysis of Electrically Evoked Cortical Potentials by Acute Suprachoroidal Electrical Stimulation of Rabbit Retina. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1778. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Acute electrical stimulation was applied on the rabbit retina with suprachoroidally implanted polyimide electrode array, and the electrically evoked cortical potentials (EECPs) were analyzed.

Methods: : The seven-channel polyimide electrode array was fabricated for animal experiment with New Zealand white rabbits. Fourteen eyes were implanted with the stimulation electrode arrays in the suprachoroidal space, and the reference electrode was placed on the scleral surface of the opposite direction from the stimulation electrode or in the vitreous cavity in each eye. Evoked cortical potentials were recorded under repetitive cathodic-first biphasic electrical stimulation of the retina (25-1000µA, 1Hz, 1ms duration, 100 averaging). Recording electrodes were implanted intradurally through stainless steel screws over the visual cortex.

Results: : In all 14 eyes, EECPs could be recorded. The mean threshold of electrical stimulation was 75.4±38.5µA in electric current, which corresponded 28.6±14.6µC/cm2 in charge density. The amplitudes of EECPs had linear correlation with the stimulation intensity, while the implicit times were not. The placement of reference electrodes on the sclera or in the vitreous cavity did not affect the results. The mean implicit time of the first negative peak was 18.6±1.5 ms in EECP while it was 21.7±1.2 ms in VEP.

Conclusions: : Electrical retinal stimulation with suprachoroidally implanted polymide electrode array could elicite EECPs in rabbits, which indicates its feasibility in retinal stimulation for artificial retina.

Keywords: retina • electrophysiology: non-clinical 
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