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M. Moriya, S. Fukuda, K. Kawana, Y. Yasuno, T. Oshika; Anterior Segment Biometry With Three-Dimensional Swept-Source Optical Coherence Tomography, Scheimpflug Camera, Scanning Slit Topography, and Ultrasound Pachymetry. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1870.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate anterior segment biometry using three-dimensional swept-source optical coherence tomography, by comparing central corneal thickness (CCT) and anterior chamber depth (ACD) obtained with other devices.
Forty eyes of 40 normal subjects (26 men and 14 women) were examined. The mean age of the subjects was 44.5 ± 20.7 (mean ± standard deviation; SD) years old. CCT and ACD were measured with 4 devices, i.e., three-dimensional cornea and anterior optical coherence tomography (3D CAS-OCT), Scheimpflug camera (SC), scanning slit topography (SST), and ultrasonic pachymetry (UP). Anterior chamber volume (ACV) was measured with 3D CAS-OCT.
A significant difference was observed in CCT measured with 4 devices (P < 0.0001, one way analysis of variance). The mean CCT was 547 ± 39.0, 590 ± 39.8, 525 ± 45.0, and 545 ± 20.7 µm with 3D CAS-OCT, SC, SST, and UP, respectively. The SC gave significantly higher CCT value than other devices (P < 0.001, Bonferroni multiple comparison). There were significant correlations between SS-OCT and SC (r = 0.639, P < 0.0001, Pearson’s correlation coefficient), SS-OCT and Orbscan (r = 0.908, P < 0.0001), and SS-OCT and USP (r = 0.977, P < 0.0001). ACD was 3.01 ± 0.47, 3.04 ± 0.52, and 2.88 ± 0.50 mm with 3D CAS-OCT, SC, SST, respectively. There were no significant differences in ACD among 3 methods (P = 0.678). In ACD measurements, there were significant correlations between 3D CAS-OCT and SC (r = 0.947, P < 0.0001), and 3D CAS-OCT and SST (r = 0.992, P < 0.0001). The mean ACV obtained with 3D CAS-OCT was 169.7 ± 23.1 mm3.
The mean CCT was equivalent among 3D CAS-OCT, SST, and UP, but CCT obtained with SC was significantly larger than those with other devices. ACD obtained with SS-OCT, SC, and SST was comparable. The 3D CAS-OCT was a useful tool to noninvasively evaluate anterior segment biometry.
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