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W. W. Phillips, S. K. Chalam, S. Gupta; Measurement of Various Layers of Huma Retina With Spectral Domain Optical Coherance Tomography in Normal Healthy Volunteers. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1882.
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A limited number of scans compromises conventional optical coherence tomography (OCT) in estimating retinal thickness accurately. Failures of edge detection algorithms falsify the results of retinal mapping even further. High-definition-OCT (SD-OCT) is based on faster scanning rate (100 times faster) with simultaneous analysis based on spectral characteristics. We investigated and compared the thickeness of retina using both instruments
22 eyes normal healthy volunteers (age ranging from 22 to 66) were imaged using a conventional time domain stratus OCT and high frequency (40khz) spectral-domain, high-speed high resolution Spectralis. Axial resolution was 6 µm; scanning speed was 25 kA-scans/second. Two different scanning patterns covering an area of 6x6mm in the macular retina were compared.
Detailed information about layer-specific distribution and volumetric measurements were obtained for retinal- and sub-RPE volumes with spectralis. Both raster scans show a high correlation (p<0.01;R2>0.89) of measured values of retinal volume and mean retinal thickness. Retinal thickness could be subdivided into three separte complexes (ganglion cell layer thickness, RPE-IS/OS complex and OS-NFL thickness). True track image technology improved repeatability of measurments (95% repeatability)
Automatic segmentation allowed for detailed quantitative and topographic analysis of the RPE and the overlying retina. Accurate measurement of various segments of retina is relvevant and useful in a variety of retinal disorders both in diagnosis and in evaluation of theraupetic response to various pharmacological agents.
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