May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Normative Data of Outer Photoreceptor Layer Thickness Obtained by Software Image Enhancing Based on Stratus Optical Coherence Tomography Images
U. C. Christensen; K. Kroyer; J. Thomadsen; T. M. Joergensen; M. la Cour; B. Sander
Author Affiliations & Notes
  • U. C. Christensen
    Glostrup Hospital, Univ. of Copenhagen, Copenhagen, Denmark
  • K. Kroyer
    Glostrup Hospital, Univ. of Copenhagen, Copenhagen, Denmark
    Dept of Ophthalmology,
  • J. Thomadsen
    Department of Optics and Plasma Research, Risø National Laboratory, Roskilde, Denmark
  • T. M. Joergensen
    Department of Optics and Plasma Research, Risø National Laboratory, Roskilde, Denmark
  • M. la Cour
    Glostrup Hospital, Univ. of Copenhagen, Copenhagen, Denmark
    Dept of Ophthalmology,
  • B. Sander
    Glostrup Hospital, Univ. of Copenhagen, Copenhagen, Denmark
    Dept of Ophthalmology,
  • Footnotes
    Commercial Relationships  U.C. Christensen, None; K. Kroyer, None; J. Thomadsen, None; T.M. Joergensen, None; M. la Cour, None; B. Sander, None.
  • Footnotes
    Support  The Danish Eye Health Society; The Danish Medical Research Council; The Velux Foundation; The John and Birthe Meyer Foundation
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1890. doi:
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      U. C. Christensen, K. Kroyer, J. Thomadsen, T. M. Joergensen, M. la Cour, B. Sander; Normative Data of Outer Photoreceptor Layer Thickness Obtained by Software Image Enhancing Based on Stratus Optical Coherence Tomography Images. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1890.

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Abstract

Purpose: : To present normative data of outer photoreceptor layer thickness obtained by a newly developed image analysis algorithm operating on software enhanced optical coherence tomography (OCT) images.

Methods: : Eight high-quality Stratus OCT3 scans from identical retinal locations from 25 normal eyes were registered and combined to form an enhanced average image. Utilizing the vertical intensity gradients of the enhanced OCT images to demarcate retinal layers, thickness measurements from the outer border of the retinal pigment epithelium to the photoreceptor inner- and outer segment junction (RPE-OScomplex) were obtained. Additionally the backscattered light within the outer nuclear layer (ONL) in the fovea was registered and compared to the backscattered light within ONL in the peripheral part of the macula (Iratio-ONL).

Results: : In healthy subjects, the mean RPE-OScomplex thickness in the foveal centre was 77.2 µm (SD = 3.95). RPE-OScomplex thickness in corresponding locations 1 mm inferior and 1 mm superior of the centre was 63.76 µm and 67.84 µm respectively. RPE-OScomplex thickness in corresponding locations 2 mm inferior and 2 mm superior of the centre was 62.16 µm and 65.36 µm respectively. The RPE-OScomplex thickness in the superior macula 0.5 mm to 3 mm of the centre was significantly increased as compared to the corresponding inferior retina (p < 0.001). In healthy subjects the intensity of backscattered light within the outer nuclear layer was identical in the central part of the retina as compared to the peripheral part ( Iratio-ONL = 1.06).

Conclusions: : Contrast enhanced OCT images enable quantification of outer photoreceptor layer thickness. We have presented normative values of outer photoreceptor layer thickness and demonstrated a difference in outer photoreceptor layer thickness between corresponding areas of inferior and superior macula. The normative values are of potential value for objectively assessing the relationship between the functional outcome and photoreceptor morphology after resolution of macular diseases.

Keywords: imaging/image analysis: clinical • macula/fovea • retina 
© 2008, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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