May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Use of Anterior Segment Optical Coherence Tomography (ASOCT) to Examine Differential Changes in Graft and Recipient Corneal Thickness After Descemet’s Stripping Automated Endothelial Keratoplasty (DSAEK)
Author Affiliations & Notes
  • J. H. Skalet
    Ophthalmology, UCSF, San Francisco, California
  • N. R. Fram
    Ophthalmology, UCSF, San Francisco, California
  • D. G. Hwang
    Ophthalmology, UCSF, San Francisco, California
  • Footnotes
    Commercial Relationships  J.H. Skalet, None; N.R. Fram, None; D.G. Hwang, None.
  • Footnotes
    Support  Supported in part by unrestricted grants from That Man May See and Research to Prevent Blindness.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1953. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J. H. Skalet, N. R. Fram, D. G. Hwang; Use of Anterior Segment Optical Coherence Tomography (ASOCT) to Examine Differential Changes in Graft and Recipient Corneal Thickness After Descemet’s Stripping Automated Endothelial Keratoplasty (DSAEK). Invest. Ophthalmol. Vis. Sci. 2008;49(13):1953. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To use ASOCT to measure post-operative changes in graft and recipient corneal thickness after DSAEK and to correlate these changes with visual recovery.

Methods: : Retrospective case review

Results: : We reviewed the records of 38 eyes from 33 consecutive patients after DSAEK performed by a single surgeon (DGH) from 2006 to 2007. Changes in total corneal thickness, donor thickness, and recipient thickness after DSAEK were evaluated and analyzed for correlation with changes in best-corrected visual acuity. For this purpose, ASOCT data were analyzed over two time intervals: from 1 week to 1 month and from 1 month to 3-6 months. Data from 14 patients were available for the first interval from 1 week to 1 month. Among these patients, total corneal thickness as measured by ASOCT decreased by a mean of 81.5 microns (p=0.004), recipient corneal thickness decreased by a mean of 65.4 microns (p=0.004), and graft thickness decreased by a mean of 16.1 microns (p=0.126, NS). In these patients, best corrected visual acuity (BCVA) improved by 2.23 lines of Snellen acuity (p = 0.0006) in the 1 week to 1 month interval. Data from 11 patients were available for the 1 month to 3-6 month interval. In the 1 month to 3-6 month interval total corneal thickness decreased by a mean of 15.5 microns (p=0.251, NS), with the recipient thickness decreasing by a mean of 35.5 microns (p=0.121, NS) and the donor tissue increasing by a mean of 20 microns (p= 0.153, NS). The BCVA improved by 0.91 lines of Snellen acuity (p= 0.027) for this interval. There is a trend towards correlation between decrease in total graft thickness and change in BCVA in the 1 week to 1 month interval (p=.082) but not in the 1 month to 3-6 month interval.

Conclusions: : ASOCT may be of particular value for following corneal thickness after DSAEK because it can differentially measure graft thickness and recipient thickness. In this small retrospective review, total corneal thickness and recipient corneal thickness each decreased significantly between one week and one month after surgery but did not change significantly between 1 month and 3-6 months after surgery. In the first month after surgery, there was a non-significant trend towards a correlation between a decrease in total corneal thickness and improvement in visual acuity. However, no such correlation was found for the interval between 1 month to 3-6 months, suggesting that further improvements in vision that occur during this time period are unlikely to be related to corneal thickness changes.

Keywords: cornea: clinical science • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×