May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Pathology of Failed Pediatric Corneal Grafts
Author Affiliations & Notes
  • B. J. Reiser
    Ophthalmology, Childrens Hospital of Los Angeles, Los Angeles, California
    Doheny Eye Institute, Los Angeles, California
  • J. C. Song
    Ophthalmology, Childrens Hospital of Los Angeles, Los Angeles, California
    Doheny Eye Institute, Los Angeles, California
  • N. Rao
    Doheny Eye Institute, Los Angeles, California
  • Footnotes
    Commercial Relationships  B.J. Reiser, None; J.C. Song, None; N. Rao, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1957. doi:https://doi.org/
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    • Get Citation

      B. J. Reiser, J. C. Song, N. Rao; Pathology of Failed Pediatric Corneal Grafts. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1957. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Very little is published in the literature regarding the pathology of graft rejection in pediatric penetrating keratoplasties despite a very high rate of failed transplants. In order to investigate a possible etiology and pathogenesis, we histologically analyzed five sequential failed grafts from patients with an original diagnosis of Peters Anomaly.

Methods: : Five cases of graft failure following corneal transplantation due to Peters anomaly were analyzed. Formalin- fixed, paraffin-embedded corneal tissue was stained with hemotoxylin and eosin and reviewed.

Results: : All grafts showed varying degrees of stromal inflammation and iris incarceration. 100% of the failed grafts showed presence of retrocorneal membranes, and 100% had absence of endothelial cells.

Conclusions: : In these failed corneal grafts, all had variable degrees of stromal inflammation. All grafts had evidence of retrocorneal corneal membranes and decimated endothelial cells.

Keywords: cornea: clinical science • pathology: human 
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