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B. J. Reiser, J. C. Song, N. Rao; Pathology of Failed Pediatric Corneal Grafts. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1957. doi: https://doi.org/.
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Very little is published in the literature regarding the pathology of graft rejection in pediatric penetrating keratoplasties despite a very high rate of failed transplants. In order to investigate a possible etiology and pathogenesis, we histologically analyzed five sequential failed grafts from patients with an original diagnosis of Peters Anomaly.
Five cases of graft failure following corneal transplantation due to Peters anomaly were analyzed. Formalin- fixed, paraffin-embedded corneal tissue was stained with hemotoxylin and eosin and reviewed.
All grafts showed varying degrees of stromal inflammation and iris incarceration. 100% of the failed grafts showed presence of retrocorneal membranes, and 100% had absence of endothelial cells.
In these failed corneal grafts, all had variable degrees of stromal inflammation. All grafts had evidence of retrocorneal corneal membranes and decimated endothelial cells.
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