May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Intraocular Pressure Variability in Observation Participants in the Ocular Hypertension Treatment Study (OHTS)
Author Affiliations & Notes
  • A. M. Bhorade
    Ophthalmology and Visual Sciences, Washington University, Saint Louis, Missouri
  • B. S. Wilson
    Ophthalmology and Visual Sciences, Washington University, Saint Louis, Missouri
  • P. Palmberg
    Ophthalmology and Visual Sciences, University of Miami, Miami, Florida
  • E. Miller
    Ophthalmology and Visual Sciences, University of Pennsylvania, Philadelphia, Pennsylvania
  • R. Weinreb
    Ophthalmology and Visual Sciences, University of San Diego, San Diego, California
  • M. A. Kass
    Ophthalmology and Visual Sciences, Washington University, Saint Louis, Missouri
  • M. O. Gordon
    Ophthalmology and Visual Sciences, Washington University, Saint Louis, Missouri
  • The Ocular Hypertension Treatment Study Group
    Ophthalmology and Visual Sciences, Washington University, Saint Louis, Missouri
  • Footnotes
    Commercial Relationships  A.M. Bhorade, None; B.S. Wilson, None; P. Palmberg, None; E. Miller, None; R. Weinreb, None; M.A. Kass, None; M.O. Gordon, None.
  • Footnotes
    Support  NIH Grants EY 09307, EY 09341, EY015498, National Center on Minority Health and Health Discparities, Merck Research Laboratories, Pfizer, Inc, unrestricted grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2048. doi:https://doi.org/
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      A. M. Bhorade, B. S. Wilson, P. Palmberg, E. Miller, R. Weinreb, M. A. Kass, M. O. Gordon, The Ocular Hypertension Treatment Study Group; Intraocular Pressure Variability in Observation Participants in the Ocular Hypertension Treatment Study (OHTS). Invest. Ophthalmol. Vis. Sci. 2008;49(13):2048. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine variability of intraocular pressure (IOP) within the same eye and between both eyes in untreated participants in the Ocular Hypertension Treatment Study (OHTS).

Methods: : Of 819 participants randomized to observation, we report on 784 participants who completed a baseline visit and follow-up visits every 6 months over a 36-month period. We calculated Pearson correlation coefficients of IOP measurements between eyes of participants on each visit and within the same eye of participants between baseline and follow-up visits. We examined the impact of "regression to the mean" and diurnal variation on the correlation between baseline and 6 month IOP measurements. The effect of measurement sequence of right and left eyes was also examined.

Results: : The correlation of IOP measurements between the two eyes of a participant at each visit ranged from r=0.65 to 0.76 over the follow-up period; the correlation of IOP measurements within the same eye ranged from r=0.32 to 0.50 between baseline and follow-up visits. The IOP in the eye with the higher baseline IOP (mean 25.9±2.9 mmHg) decreased a mean of 0.7±3.6 mmHg at 6 months whereas the eye with the lower baseline IOP (mean 24.0±2.8 mmHg) remained relatively unchanged with a mean of 0.0±3.1mmHg. The correlation of IOP measured less than or equal to 2 hours vs. greater than 4 hours of the same time of day between baseline and 6 month visits were r=0.54 and r=0.33 respectively. The mean IOP of the right eye, which was measured first, was 0.2-0.4 mmHg higher than the left eye at each visit.

Clinical Trial: : www.clinicaltrials.gov NCT00000125

Keywords: intraocular pressure 
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