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A. M. Bhorade, B. S. Wilson, P. Palmberg, E. Miller, R. Weinreb, M. A. Kass, M. O. Gordon, The Ocular Hypertension Treatment Study Group; Intraocular Pressure Variability in Observation Participants in the Ocular Hypertension Treatment Study (OHTS). Invest. Ophthalmol. Vis. Sci. 2008;49(13):2048.
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To determine variability of intraocular pressure (IOP) within the same eye and between both eyes in untreated participants in the Ocular Hypertension Treatment Study (OHTS).
Of 819 participants randomized to observation, we report on 784 participants who completed a baseline visit and follow-up visits every 6 months over a 36-month period. We calculated Pearson correlation coefficients of IOP measurements between eyes of participants on each visit and within the same eye of participants between baseline and follow-up visits. We examined the impact of "regression to the mean" and diurnal variation on the correlation between baseline and 6 month IOP measurements. The effect of measurement sequence of right and left eyes was also examined.
The correlation of IOP measurements between the two eyes of a participant at each visit ranged from r=0.65 to 0.76 over the follow-up period; the correlation of IOP measurements within the same eye ranged from r=0.32 to 0.50 between baseline and follow-up visits. The IOP in the eye with the higher baseline IOP (mean 25.9Â±2.9 mmHg) decreased a mean of 0.7Â±3.6 mmHg at 6 months whereas the eye with the lower baseline IOP (mean 24.0Â±2.8 mmHg) remained relatively unchanged with a mean of 0.0Â±3.1mmHg. The correlation of IOP measured less than or equal to 2 hours vs. greater than 4 hours of the same time of day between baseline and 6 month visits were r=0.54 and r=0.33 respectively. The mean IOP of the right eye, which was measured first, was 0.2-0.4 mmHg higher than the left eye at each visit.
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