May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Clinical Results, OCT, Multifocal ERG and Lesion Diameter in Eyes Two and Six Years After Autologous Retinal Pigment Epithelium Cell Transplantation
Author Affiliations & Notes
  • S. Binder
    Ophthalmology, Rudolph Foundation Clinic, Vienna, Austria
    Ophthalmology, Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Vienna, Austria
  • S. Hagen
    Ophthalmology, Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Vienna, Austria
  • P. Haas
    Ophthalmology, Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Vienna, Austria
  • I. Krebs
    Ophthalmology, Rudolph Foundation Clinic, Vienna, Austria
    Ophthalmology, Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Vienna, Austria
  • Footnotes
    Commercial Relationships  S. Binder, None; S. Hagen, None; P. Haas, None; I. Krebs, None.
  • Footnotes
    Support  "none"
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2056. doi:https://doi.org/
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      S. Binder, S. Hagen, P. Haas, I. Krebs; Clinical Results, OCT, Multifocal ERG and Lesion Diameter in Eyes Two and Six Years After Autologous Retinal Pigment Epithelium Cell Transplantation. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2056. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate late term results two and six years after choroidal neovascular membrane (CNV) excision combined with autologous retinal pigmentepithelium cell transplantation.Material and

Methods: : From initial 39 patients 17 completed follow up two and six years after intervention. Parameters evaluated include distance visual acuity (VA), tested with Early Treatment Diabetic Retinopathy Study charts, reading acuity, examined with Jaeger (Jg) charts fluorescein angiography (FA), optical coherence tomography and multifocal electroretinography (mfERG) examinations.

Results: : Seventeen eyes of 17 patients were included in this study. Their mean age was 81,4 ± 8,5 years, ranging from 58 to 92 years. In two patients the study eye was their only functional eye. Throughout the observation period recurrences of CNV only were present in three eyes at the two year examination.Mean distance VA at baseline and after two years was 5,2 ± 6,0 and 14,9 ± 25,1 (p=0,14) letters respectively. Compared to baseline, at the six year follow up mean VA was 12,6 ± 26 (p=0,26) letters.Two years after intervention mean reading acuity significantly improved from Jg 16,5 ± 0,72 to 14,5 ± 3,61 (p=0,034). At the 6 year follow up mean reading acuity was Jg 15,7 ± 3,69, not significant to baseline (p=0,38).Three months after intervention mean retinal thickness was 236,7 ± 57,7 µm. After two and six years mean retinal thickness was 209,5 ± 52,2 (p=0,16) and 216,2 ± 56,1 (p=0,30) respectively. The mean maximum mfERG response at baseline was 92,8 ± 30,8 nV/deg2. At the 2 and 6 year visit respective values were 84 ± 40,3 (p=0,48) and 116 ± 52,9 nV/deg2 (p=0,13).A change of the mean maximum lesion diameter from 4,8 ± 1,7 mm at baseline to 5,4 ± 1,5 mm (p= 0,27) after two years and 6,1 ± 1,9 mm (p=0,041) after 6 years was observed.

Clinical Trial: : www.clinicaltrials.gov NCT00401713

Keywords: age-related macular degeneration • retina • choroid: neovascularization 
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