May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Age Dependence of Spontaneous Dynamic Retinal Vessel Behaviour
Author Affiliations & Notes
  • K. E. Kotliar
    Technical University Munich, Munich, Germany
    Ophthalmology,
  • W. Vilser
    Biomedical Engineering, Technical University Ilmenau, Ilmenau, Germany
  • M. Halle
    Technical University Munich, Munich, Germany
    Preventive Sport Medicine,
  • A. Schmidt-Trucksaess
    Technical University Munich, Munich, Germany
    Preventive Sport Medicine,
  • I. M. Lanzl
    Technical University Munich, Munich, Germany
    Ophthalmology,
  • Footnotes
    Commercial Relationships  K.E. Kotliar, None; W. Vilser, IMEDOS.Ltd, E; M. Halle, None; A. Schmidt-Trucksaess, None; I.M. Lanzl, None.
  • Footnotes
    Support  KKF Foundation, Medical Clinic, Munich University of Technology
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2084. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      K. E. Kotliar, W. Vilser, M. Halle, A. Schmidt-Trucksaess, I. M. Lanzl; Age Dependence of Spontaneous Dynamic Retinal Vessel Behaviour. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2084. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : By image analysis it is possible to observe retinal vessels in their dynamic state online. Vessel diameters can be measured continuously along a given vessel segment with the Dynamic Vessel Analyzer (DVA, Fa. IMEDOS, Jena). Continuous signals can be mathematically analyzed using cross- and autocorellation analysis. The aim is to investigate a difference in spontaneous dynamic behaviour of retinal vessels in healthy persons of different age.

Methods: : Time dependent retinal vessel reaction was measured in the right eye of 28 medically healthy volunteers. The volunteers were divided in 2 age groups of 14 persons each: youngs (21-32 years) and seniors (52-70 years). Vessel diameters of a retinal arterial and venous vessel segment were examined with DVA during 40 seconds in all subjects. Temporal vessel behavior was evaluated using methods of signal analysis. Oscillatory temporal changes of vessel diameter were divided into high-frequent (period < 1.5 s) and low-frequent (period ≥ 1.5 s).

Results: : Phase difference between temporal arterial and venous vessel diameter changes was significantly higher in the young group (0.6(0.1;3.3) s (median(1. quartile;3. quartile)) compared to the senior group (0.1(-0.4;0.3) s) (p<0.03). In veins there was a significant difference in the rate of periodicity (RP) between the groups (p<0.01). In the senior group there was a significant difference in RP between arteries and veins (p<0.01).

Conclusions: : High-frequency oscillations of vessel diameter correspond to the heart pulse rate and were more expressed in the senior group. We were able to see high-frequency changes in venous diameter (spontaneous venous pulse) in the majority of healthy subjects independent of age. Low-frequency oscillations with a period of 6-15 s were well expressed in healthy youngs. Our results show significant difference between arterial and venous temporal vessel behavior as well as between vessel reactions in both age groups. These findings in dynamic vessel behaviour in aging might be an indication for age-specific changes of vascular endothelium and vessel wall rigidity leading to alterations in the retinal autoregulation.

Keywords: aging • blood supply • retina 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×