May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Hypoxia in Human Central Retinal Vein Occlusion
Author Affiliations & Notes
  • S. Traustason
    University of Iceland, Reykjavik, Iceland
    Department of Ophthalmology,
  • S. H. Hardarson
    University of Iceland, Reykjavik, Iceland
    Department of Ophthalmology,
  • G. H. Halldorsson
    University of Iceland, Reykjavik, Iceland
    Electrical and Computer Engineering,
  • R. A. Karlsson
    University of Iceland, Reykjavik, Iceland
    Electrical and Computer Engineering,
  • J. M. Beach
    University of Iceland, Reykjavik, Iceland
    Electrical and Computer Engineering,
  • J. A. Benediktsson
    University of Iceland, Reykjavik, Iceland
    Electrical and Computer Engineering,
  • T. Eysteinsson
    University of Iceland, Reykjavik, Iceland
    Department of Ophthalmology,
  • E. Stefansson
    University of Iceland, Reykjavik, Iceland
    Department of Ophthalmology,
  • Footnotes
    Commercial Relationships  S. Traustason, Oxymap, E; S.H. Hardarson, Oxymap, I; Oxymap, E; Oxymap, P; G.H. Halldorsson, Oxymap, I; Oxymap, E; Oxymap, P; R.A. Karlsson, Oxymap, I; Oxymap, E; Oxymap, P; J.M. Beach, Oxymap, I; Oxymap, E; Oxymap, P; J.A. Benediktsson, Oxymap, I; Oxymap, P; T. Eysteinsson, Oxymap, I; Oxymap, P; E. Stefansson, Oxymap, I; Oxymap, P.
  • Footnotes
    Support  Icelandic Research Council, Eimskip University Fund, Landspitali Research Fund, Helga Jonsdottir and Sigurlidi Kristjansson Memorial Fund, University of Iceland Research Fund
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2093. doi:https://doi.org/
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    • Get Citation

      S. Traustason, S. H. Hardarson, G. H. Halldorsson, R. A. Karlsson, J. M. Beach, J. A. Benediktsson, T. Eysteinsson, E. Stefansson; Hypoxia in Human Central Retinal Vein Occlusion. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2093. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To non-invasively measure oxygen saturation in retinal vesselsin patients with central retinal vein occlusion (CRVO).

 
Methods:
 

The retinal oximeter is composed of a fundus camera, beam splitterand a digital camera. It yields fundus images with isosbesticand non-isosbestic wavelengths of light simultaneously. Custom-designedsoftware analyzes the images and estimates oxygen saturation.Measurementswere made on 5 individuals with CRVO. Oxygen saturation wasmeasured in 1st and 2nd degree vessels within 2 disc diametersfrom the optic disc. Mean saturation levels were calculatedfor each eye and paired t-tests were used for statistical analysis.

 
Results:
 

The table below summarizes the oxygen saturation measurementsand statistical analysis.Variabilityin venous oxygen saturation within eyes is considerable, assome venules show near normal levels of oxygen saturation (seeimage below).  

 

 
Conclusions:
 

Variable levels of hypoxia were observed in retinal venulesin patients with CRVO. Mean venous oxygen saturation is lowerin CRVO affected eyes than in fellow eyes, but differences inarterial saturation are not significant.

 
Keywords: vascular occlusion/vascular occlusive disease • oxygen • imaging/image analysis: clinical 
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