May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Loss of Circadian Rhythm of IOP Following Cervical Ganglionectomy in Rats
Author Affiliations & Notes
  • T. Kim
    Ophthalmology, Gyeongsang National University Hospital, Jinju, Republic of Korea
  • S. Seo
    Ophthalmology, Gyeongsang National University Hospital, Jinju, Republic of Korea
  • I. Chung
    Ophthalmology, Gyeongsang National University Hospital, Jinju, Republic of Korea
  • N. Lim
    Ophthalmology, Gyeongsang National University Hospital, Jinju, Republic of Korea
  • Y. Park
    Ophthalmology, Gyeongsang National University Hospital, Jinju, Republic of Korea
  • K. Kim
    Ophthalmology, Gyeongsang National University Hospital, Jinju, Republic of Korea
  • S. Lee
    Ophthalmology, Chungnam National University Hospital, Daejun, Republic of Korea
  • Footnotes
    Commercial Relationships  T. Kim, None; S. Seo, None; I. Chung, None; N. Lim, None; Y. Park, None; K. Kim, None; S. Lee, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2094. doi:https://doi.org/
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    • Get Citation

      T. Kim, S. Seo, I. Chung, N. Lim, Y. Park, K. Kim, S. Lee; Loss of Circadian Rhythm of IOP Following Cervical Ganglionectomy in Rats. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2094. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To investigate whether ocular sympathetic activities involvein the circadian rhythm of intraocular pressure(IOP) in therat.

 
Methods:
 

Sprague-Dawley rats were entrained in a daily 12-hour light/12-hourdark cycle for 3 weeks (n=9). Circadian time 6 to 18 o’clockwas the subjective light phase. We measured the IOP of botheyes every 4 hr with Tonopen-XL tonometer in awake state duringthe circadian 24 hrs. The average of repeated 10 values of IOPwas calculated at each time. Then unilateral cervical ganglionectomywas done on these rats (n=9). Sympathetic innervation to theeye was destroyed by surgical removal of the right superiorcervical ganglion (superior cervical ganglionectomy; SCGx).We measured the IOPs at postoperative 1, 2, 3 and 4 weeks inthe same way during the same circadian cycle. Statistical analysiswas done by T-test and F-test(one way ANOVA) using SPSS 12.0processor. All surgical procedures were approved by InstitutionalAnimalCare and Use Committee at Gyeongsang National Universityand conformed to the ARVO statement for the Use of Animals inOphthalmic and Vision Research.

 
Results:
 

Rat has a circadian rhythm of IOP which was higher in the darkthan in the light. But, after cervical ganglionectomy the circadianrhythm of IOP was disappeared and the change of circadian rhythmwas maintained until 4 weeks later.

 
Conclusions:
 

Ocular sympathetic activities may play a role in the circadianrhythm of IOP in the rat.  

 

 
Keywords: circadian rhythms • intraocular pressure 
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