May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Prevalence of Subfoveal Nodule in Coat’s Disease
Author Affiliations & Notes
  • H. V. Tran
    Inherited Retinal Disease, Jules Gonin University Eye Hospital, Lausanne, Switzerland
    Molecular Therapy, Institute of Ophthalmology, UCL, London, United Kingdom
  • C. Stathopoulos
    Inherited Retinal Disease, Jules Gonin University Eye Hospital, Lausanne, Switzerland
  • A. Balmer
    Inherited Retinal Disease, Jules Gonin University Eye Hospital, Lausanne, Switzerland
  • H. Abou-Zeid
    Inherited Retinal Disease, Jules Gonin University Eye Hospital, Lausanne, Switzerland
  • L. Zografos
    Inherited Retinal Disease, Jules Gonin University Eye Hospital, Lausanne, Switzerland
  • D. Schorderet
    Institute for Research in Ophthalmology, Sion, Switzerland
  • F. L. Munier
    Inherited Retinal Disease, Jules Gonin University Eye Hospital, Lausanne, Switzerland
  • Footnotes
    Commercial Relationships  H.V. Tran, None; C. Stathopoulos, None; A. Balmer, None; H. Abou-Zeid, None; L. Zografos, None; D. Schorderet, None; F.L. Munier, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2130. doi:https://doi.org/
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    • Get Citation

      H. V. Tran, C. Stathopoulos, A. Balmer, H. Abou-Zeid, L. Zografos, D. Schorderet, F. L. Munier; Prevalence of Subfoveal Nodule in Coat’s Disease. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2130. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Coats' disease is a non-hereditary condition characterized by idiopathic retinal telangiectasia, and exudative retinopathy. Although the exudation often spreads from the main areas of telangiectasia, there is a preferential accumulation of exudation in the macular area in Coats' disease. A subfoveal nodule has usually been described in the context of resolution of macular exudates after treatment of peripheral retinal telangiectasis. Nevertheless, a recent reports stressed out an uncommon prominent subfoveal nodule with peripheral exudates as initial presentation of Coats'disease. The purpose of this study was to report the prevalence of this presentation in a cohort of patients.

Methods: : All consecutive patients with Coats' disease referred to the Jules Gonin Eye Hospital between January 1979 and July 2006 were included. All charts were screened for a clear cut subfoveal circular lesion on fundus photographies at initial presentation.

Results: : 95 patients suffering of Coat's disease were enrolled. 33 out of 95 patients had subtotal or total exudative retinal detachment, which impeded macular examination. 14 out of 62 (22.6%) resting patients presented with a clear cut prominent circular subfoveal lesion at initial presentation. All patients had unilateral disease. Mean age was 5.6 ± 3.5 year old at initial presentation. There were 4 females and 10 males. Pigmentation and size of the nodule were not homogenous. Mean diameter was 1.1 ± 0.5 optic disc diameter.

Conclusions: : The present study shows that subfoveal nodule is not such a rare primary presentation of Coats' disease in contrast to what it has been previously reported in the literature. Thus the initial finding of prominent subfoveal nodule associated with peripheral retinal findings made the diagnosis of Coats' disease highly likely.Physicians should be aware that a proeminent subfoveal nodule is a common initial presentation of Coats' disease as it can be confused clinically with Retinoblastoma.

Keywords: macula/fovea • tumors • retinal development 
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