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K. Warren, B. A. Blodi, N. Oden, P. Van Veldhuisen, I. U. Scott, M. Ip, SCORE Study Group; Reading Center Evaluation of Baseline Retinal Images in the Standard Care vs. Corticosteroid for Retinal Vein Occlusion (SCORE) Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2136.
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The SCORE Study consists of 2 multicenter randomized trials investigating the safety and efficacy of standard of care vs. intravitreal triamcinolone to treat branch and central retinal vein occlusion. We present the Fundus Photograph Reading Center (FPRC) evaluation of baseline color fundus photographs (FP), fluorescein angiograms (FA) and optical coherence tomograms (OCT) of SCORE participants.
FP are evaluated for the area of retinal edema and hemorrhage within a 16 disc area macular grid; FA are evaluated for the area of leakage and OCT scans are evaluated for retinal thickening within the grid.
Baseline FPRC evaluation for 540 patients enrolled through September 2007 included 331 BRVO participants and 209 CRVO participants. There was a mean of 7.4 disc areas (DA) of retinal edema within the grid for BRVO participants and 12.1 DA of edema for CRVO participants (p < 0.0001, t-test). Retinal hemorrhage within the grid had a mean of 3.0 DA in BRVO and 3.5 DA in CRVO participants (p = 0.19). The mean area of leakage within the grid on FA was 6.0 DA for BRVO participants and 10.9 DA for CRVO participants (p < 0.0001). OCT showed a significant difference in the mean central point thickness between the two groups (524um for BRVO and 655um for CRVO; p = 0.001). There was no difference between inferior and superior BRVOs in terms of area of retinal edema, retinal hemorrhage, FA leakage, and OCT center point thickness.
In the SCORE Study, CRVO participants present at baseline with a significantly greater area of retinal edema, fluorescein leakage, and center point thickness on OCT. The area of retinal hemorrhage does not differ significantly between the BRVO and CRVO groups. The significantly greater area of retinal edema, leakage and thickening in CRVO participants may reflect a biological difference in the two types of venous occlusion.
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