May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Relationship Between HLA Class II Alleles and Proliferative Diabetic Retinopathy in Mexican Patients With Type 2 Diabetes Mellitus (T2D)
Author Affiliations & Notes
  • H. Quiroz-Mercado
    Retina Service, Asoc para Evitar la Ceguera, Mexico City, Mexico
  • C. Sanchez-Noguera
    Retina Service, Asoc para Evitar la Ceguera, Mexico City, Mexico
  • J. Fromow-Guerra
    Retina Service, Asoc para Evitar la Ceguera, Mexico City, Mexico
  • N. Salazar-Teran
    Retina Service, Asoc para Evitar la Ceguera, Mexico City, Mexico
  • M. Martinez-Castellanos
    Retina Service, Asoc para Evitar la Ceguera, Mexico City, Mexico
  • R. Velez-Montoya
    Retina Service, Asoc para Evitar la Ceguera, Mexico City, Mexico
  • A. Solis-Vivanco
    Retina Service, Asoc para Evitar la Ceguera, Mexico City, Mexico
  • C. Alaez
    Immunology & Immunogenetics, InDRE, Mexico City, Mexico
  • C. Gorodezky
    Immunology & Immunogenetics, InDRE, Mexico City, Mexico
  • Footnotes
    Commercial Relationships  H. Quiroz-Mercado, None; C. Sanchez-Noguera, None; J. Fromow-Guerra, None; N. Salazar-Teran, None; M. Martinez-Castellanos, None; R. Velez-Montoya, None; A. Solis-Vivanco, None; C. Alaez, None; C. Gorodezky, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2149. doi:
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    • Get Citation

      H. Quiroz-Mercado, C. Sanchez-Noguera, J. Fromow-Guerra, N. Salazar-Teran, M. Martinez-Castellanos, R. Velez-Montoya, A. Solis-Vivanco, C. Alaez, C. Gorodezky; Relationship Between HLA Class II Alleles and Proliferative Diabetic Retinopathy in Mexican Patients With Type 2 Diabetes Mellitus (T2D). Invest. Ophthalmol. Vis. Sci. 2008;49(13):2149.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the association between retinopathy and HLA Class II alleles in T2D.

Methods: : We designed a case-control study in which 124 mestizo Mexican patients with an at least 10 years of T2D and diabetic retinopathy. DNA was extracted and HLA-DR regions were amplified using PCR. Alleles were determined by DNA hybridization. Diagnosis was assessed clinically. Incidence of HLA-DR alleles in patients was compared with ethnically matched control group of healthy subject (n=238) and patients with proliferative diabetic retinopathy (PDR)(n=65). Statistical significance was established with non-parametric test

Results: : Patients with PDR showed an association the alleles of DRB1*1406 when compared to the controls (p=0.03, OR=2.2). No differences was found when DRB1 and DQB1 were compared between the groups

Conclusions: : We suggest that the allele of Amerindian ancestry (DRB1*1406) with additive minor effects, contribute to the expression of PDR in Mexican patients with T2D

Keywords: antigen presentation/processing • diabetic retinopathy • development 
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