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Y. Ito, M. Kondo, S. Kachi, M. Nakamura, T. Asano, H. Terasaki; Increased Macular Volume at Onset Followed by Gradual Decrease in Eyes With Acute Zonal Occult Outer Retinopathy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2170. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the changes in macular volume in the acute phase of acute zonal occult outer retinopathy (AZOOR) in three eyes.
Case 1 was a 33-year-old woman who presented with a central scotoma in her left eye of 3 day duration. Her best corrected visual acuity (BCVA) was 20/20 OD and 20/200 OS. Case 2 was a 43-year-old woman who presented with a temporal visual filed defect in her right eye of 11 day duration. Her BCVA was 20/22 OD and 20/20 OS. Case 3 was a 19-year-old woman who presented with a central scotoma in her right eye of 6 day duration. Her BCVA was 20/33 OD and 20/20 OS. The macular volume in the central 6 mm was measured by optical coherence tomography in the acute phase and were compared with that of fellow eyes, and with 9 eyes diagnosed with AZOOR in the chronic phase (mean age, 30.6 years; range, 23-44 years). The interval between the onset and OCT examination was 3, 11, and 6 days in the acute phase and 29.6 months (6-96 months) in the 9 eyes in the chronic phase.
The results of slit-lamp biomicroscopy and ophthalmoscopy were normal in the 3 eyes, but the amplitudes of the a- and b-waves of the focal macular ERGs were reduced. Optical coherence tomography showed an increase in the macular volume in the affected eyes at the initial examination and a gradual decrease with increasing time in all cases. In Case 1, the macular volume progressively decreased for about 2 months and then stopped. The macular volume in the central 6 mm of the left eye was 6.863 mm3 at the initial examination, 6.621 mm3 2 weeks later, and 6.384 mm3 6 week later. In Case 2, the macular volume decreased after 6 months. The macular volume in the right eye was 7.092 mm3 at the first examination and 6.225 mm3 6 months later. In Case 3, the macular volume decreased after 1 month and did not change thereafter. The macular volume was 8.203 mm3 at the first examination, 8.09 mm3 2 weeks later and 7.936 mm3 1 month later. These volume changes were not observed in the fellow eyes or the 9 AZOOR eyes in the chronic phase.
In eyes with AZOOR, the increased macula volume at the onset decreases for 1 or 2 months. The decrease results from an atrophy of the retina. Although treatment for AZOOR has not been established, if treatment is considered for AZOOR, it should be started in the acute phase before retinal atrophy is observed.
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