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H. Sasaki, Y. Mitamura, S. Aizawa, T. Baba, A. Hagiwara, S. Yamamoto; Correlation Between OCT Findings and Retinal Sensitivity in Patients With Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2176.
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To determine whether a significant correlation exists between the OCT findings and retinal sensitivity in patients with retinitis pigmentosa (RP).
Sixty-four eyes of 34 patients with RP were examined by the optical coherence tomography (OCT) 3 and the Micro Perimeter-1 (MP-1). The photoreceptor inner and outer segment junction (IS/OS) appeared as a distinct, highly reflective line just vitread of the retinal pigment epithelium in the OCT3 images. The length of the IS/OS line was measured in the grayscale OCT3 images obtained from 5-mm horizontal scans through the fovea. The central foveal thickness (CFT) and retinal volume (RV) were also calculated. The MP-1 was used to determine the mean retinal sensitivity at 24 locations covering the central 10°. The correlation between the retinal sensitivity and the length of the IS/OS line, CRT, or RV was determined.
The length of the IS/OS line was significantly correlated with the retinal sensitivity (r=0.618, P<0.0001). However, correlations between the retinal sensitivity and CRT or RV were not significant (r=0.109, P=0.3939; R=0.129, P=0.3120; respectively).
The length of the IS/OS line was associated with the retinal sensitivity in RP patients. The length of the IS/OS may reflect a retinal function and may be an important additional parameter to monitor RP patients.
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