May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Erythropoietin Therapy in a Patient Suffering From Retinitis Pigmentosa and Sideroblastic Anemia
Author Affiliations & Notes
  • O. Roche
    Hopital Necker Enfants-Malades, Paris, France
    Ophtalmologie,
  • F. Suarez
    Hopital Necker Enfants-Malades, Paris, France
    Hematology,
  • J. Rozet
    Hopital Necker Enfants-Malades, Paris, France
    Genetics,
  • J. Kaplan
    Hopital Necker Enfants-Malades, Paris, France
    Genetics,
  • H. Dollfus
    Laboratoire de diagnostic génétique, Louis Pasteur University Medical School, Strasbourg, France
  • O. Hermine
    Hopital Necker Enfants-Malades, Paris, France
    Hematology,
  • J.-L. Dufier
    Hopital Necker Enfants-Malades, Paris, France
    Ophtalmologie,
  • Footnotes
    Commercial Relationships  O. Roche, None; F. Suarez, None; J. Rozet, None; J. Kaplan, None; H. Dollfus, None; O. Hermine, None; J. Dufier, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2179. doi:https://doi.org/
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      O. Roche, F. Suarez, J. Rozet, J. Kaplan, H. Dollfus, O. Hermine, J.-L. Dufier; Erythropoietin Therapy in a Patient Suffering From Retinitis Pigmentosa and Sideroblastic Anemia. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2179. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To report a patient with severe RP leading to blindness who was treated with rEpo for an associated congenital sideroblastic anemia.

Methods: : A 19-year-old male with Bardet-Biedl syndrome that included a classical, bilateral pigmentary retinopathy with secondary blindness, was treated with recombinant erythropoietin for an associated congenital sideroblastic anemia.

Results: : During the 12-month follow-up, there was a dramatic improvement of the visual acuity (20/2000 to 20/50), visual fields and retinal electrophysiological activity as well as an increase of the retinal thickness, while hematological parameters remained unchanged.

Conclusions: : rEpo treatment had no effect on the Hb level but was followed by a dramatic improvement of visual acuity and objective ophtalmologic parameters suggesting a direct effect of Epo on the retina.This provocative case report supports the concept that erythropoietin may act as a retinal growth factor and may be of benefit to a subset of patients with retinitis pigmentosa.

Keywords: retina • retinitis • regeneration 
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