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H. Nakamura, A. Oishi, M. Sasahara, H. Kojima, M. Kurimoto, A. Otani, N. Yoshimura; The Evaluation of Retinal Function in Each Layers of The Macula in Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2181.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the correlation between focal electroretinograms (ERG) and retinal thickness in each layers of the macula in patients with retinitis pigmentosa.
All 16 patients (49.9±19.3 years) with retinitis pigmentosa had a good best corrected Snellen visual acuities of 30/20 to 14/20, no visible macular cysts and no epiretinal membrane. We recorded focal ERGs and optical coherence tomography (OCT) in the macular regions from 16 eyes (16 patients). Spectral-domain optical coherence tomography (RTVue-100) was used to measure outer and inner retinal layer thickness in fovea, parafovea and perifovea. Focal ERGs were elicited by a 15 degrees stimulus centered on the fovea and monitored by an infrared fundus camera. The amplitudes and implicit times of the a- and b-waves and oscillatory potentials (OPs) were compared with the retinal thickness of inner and outer layer in the fovea, parafovea and perifovea, respectively.
We recorded a- and b-waves and OPs in 16 eyes of all 16 patients. The mean amplitudes (±S.D.), respectively, were: a wave, 0.9±0.5 µV; b wave, 2.3±1.2 µV and OP, 0.6±0.3 µV. The mean implicit times (±S.D.), respectively, were: a wave, 21.9±1.8 ms; b wave, 42.3±3.5 ms and OP, 34.0±1.9 ms. The average retinal thickness (±S.D.) were 162.5±10.1 µm, 76.4±13.7 µm; 165.8±13.8 µm, 115.8±11.6 µm; 139.5±17.3 µm, 98.8±12.1 µm in outer layer and inner layer, respectively, in fovea, parafovea and perifovea. The a-wave amplitude showed a significant correlation with the retinal thickness in outer layer not in inner layer in perifovea (r2 = 0.30, p<0.05) but not in fovea and parafovea. The b-wave and OP amplitude showed a significant correlation with the retinal thickness in outer layer not in inner layer in parafovea (r2 = 0.32, p<0.05; r2 = 0.41, p<0.005, respectively) and in outer layer and inner layer in perifovea (r2 = 0.37, p<0.01 and r2 = 0.33, p<0.05; r2 = 0.52, p=0.001 and r2 = 0.43, p<0.005; in the b-wave and OP, respectively). There were no significant correlation between the implicit times and retinal thickness.
These results suggest that focal ERG is associated with the outer retinal function in parafovea and perifovea rather than fovea in early stage of retinitis pigmentosa.
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