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M. Fei, Jr.; The Characters of Multifocal Electroretinograms in Normal Guinea Pigs. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2219.
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To study the characters of multifocal electroretinograms in normal guinea pigs
mfERG were recorded in 20 guinea pigs using the method established by our lab in photopic adaptation. During the recording, we change recording conditions including frames and stimulus colors. There was 3 day break between each time of recording for guinea pigs’ recover from anesthesia.
The P1 wave amplitude sum of guinea pigs’ mf ERGs was (54.95±3.22)µV and the latency sum was (30.25 ±1.94) ms. The P1 amplitudes of superior testing field was larger than that of inferior field (P<0.05). The amplitude decreased as the eccentricity increased ( P < 0.05) . When in higher frames (>2), mfERG waves could be recorded. Repeatly record had no significant effect on the testing outcome (P > 0.05).
Guinea pigs has more cones than Muridae, such as rats and mice and their retina contains at least two different types of cone photoreceptor pigments so that they have at least two classes of cones with peak sensitivities of 429 and 529 nm. According to this, so we can get mfERG waves in photopic adaptation. The amplitude changes with eccentricity may be related to the distribution of photoreceptors in guinea pigs’ retina while difference of amplitudes between superior and inferior part of testing field may be related to guinea pigs’ habits. The recording procedure founded by our lab can evaluate the retinal function of guinea pigs reliably and quantitatively.
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