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S. Ozawa, K. Ishikawa, H. Nishihara, T. Yamakoshi, Y. Hatta, E. Iwata, K. Takeuchi, H. Terasaki; OCT-Determined Macular Morphology in Eyes With Occult Choroidal Neovascularization Secondary to Age-Related Macular Degeneration or Secondary to Polypoidal Choroidal Vasculopathy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2228.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the differences in the optical coherence tomography (OCT)-determined macular morphology in Japanese patients with occult choroidal neovascularization (CNV) secondary to typical age-related macular degeneration (AMD) to that in eyes with occult CNV secondary to polypoidal choroidal vasculopathy (PCV).
One hundred thirty-seven eyes of 136 consecutive patients with only occult CNV that had not received any treatment were studied. The CNV was secondary to AMD in 53 eyes (39%) and to PCV in 84 eyes (61%). The OCT images, fluorescein angiograms (FA), and Indocyanine green angiograms (ICGA) obtained before photodynamic therapy or intravitreal injection of bevacizumab were examined. The presence or absence of serous retinal detachment (SRD) was determined from the OCT images, and pigment epithelial detachment (PED) from the FA and ICGA images. The thickness of the neurosensory retina and SRD within a 3 mm diameter circle centered on the fovea was measured with a computer algorithm which can analyze the OCT images and determine the retinal thickness.
SRDs were observed in 30/53 (57%) eyes with AMD and in 62/84 (74%) eyes with PCV (P=0.042). PEDs were seen in 20/53 (38%) eyes with AMD and in 25/84 (30%) eyes with PCV (P=0.355). The mean thickness of the SRD within a central 3 mm area was 22.4 ± 4.0 µm (mean ± SEMs) in eyes with AMD and 55.7 ± 7.6 in eyes with PCV (P=0.007). The mean thickness of the neurosensory retina within a central 3 mm area was 286.6 ± 6.2 µm in eyes with AMD and 277.7 ± 5.0 in eyes with PCV (P=0.264). The frequency of SRD >100 µm was 2/53 (4%) eyes with AMD and 19/84 (23%) eyes with PCV (P=0.003).
PCV was detected in approximately 60% of the eyes with occult CNV. The frequency of the SRD was significantly higher in eyes with PCV than that in eyes with AMD, especially in eyes with large SRD. The mean thickness of the SRD was significantly greater in eyes with PCV than that in eyes with AMD.
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