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A. Domalpally, J. Elledge, B. A. Blodi, R. P. Danis, B. Zhang, L. Hubbard, FPRC NeoAMD Grading Group; Comparison of Fluorescein Angiography and Optical Coherence Tomography Features of Neovascular Age Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2230.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the baseline fluorescein angiographic (FA) features of neovascular age related macular degeneration(Neo AMD) with morphological abnormalities on optical coherence tomography (OCT)
Baseline visits of eleven multicenter Neo AMD clinical trials with both FA and OCT images were included. All images were evaluated by trained and certified ocular disease evaluators. Each image type was evaluated independently. FA grading variables included CNV subtype, its area and proximity to the center of the macula, and the area of leakage. OCT grading variables included were centerpoint thickness (CPT), total macular volume (TMV) ,presence of cysts and subretinal fluid (SRF) presence. SRF height was measured if the centerpoint was involved
Data available from 730 eyes with previously evaluated FAs and OCTs was analyzed. 667(91.3%) of the eyes were predominantly CNV, with the remaining having most of the lesion area occupied by non-CNV lesion components. Of the predominantly CNV eyes, 69% were predominantly occult (P Occ) and 27% predominantly classic (PClassic). 89.3% of the CNV lesions were subfoveal with a median lesion area of 3.1DA. Leakage was seen in 713(97.5%) of eyes. By OCT, the median CPT and TMV were 304.5µ and 7.42 mm3. OCT confirmed SRF was present in 375 eyes (51.5%) and of these 37% involved the centerpoint. OCT confirmed cysts were present in 375(51%) eyes.OCTs with centerpoint thickness ≥ 250µ were more frequent in the PClassic group (144/179, 80%) compared to the POcc group (281/462; 62%);p<0.001. Leakage area on FA did not correlate to CPT, TMV and SRF thickness at centerpoint. Of the eyes that had leakage, subretinal fluid was present in 371(52%) and cysts were present in 327(46%).
Increased CTP on OCT is more frequent in the predominantly classic subgroup. Angiographic leakage does not correlate well with retinal morphological features on OCT.
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