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G. O. Waring, IV, D. S. Durrie, J. E. Sutphin, Jr., J. E. Stahl; Three Dimensional Endoscopic Confocal Corneal "Fly Through" Video for Qualitative Analysis of the Cornea Following AcuFocusTM Corneal Inlay. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2260.
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© ARVO (1962-2015); The Authors (2016-present)
To demonstrate qualitative analysis of the corneal anatomy following AcuFocusTM corneal inlay (Irvine, CA) using three and four dimensional endoscopic confocal renderings.
A single patient with a unilateral AcuFocus corneal inlay underwent confocal microscopy with the ConfoScan 4 (Nidek, Inc., Fremont, CA) using the Z-ring for ocular stabilization, a single scan pass and a 2 micron step size. The same technique was used with a normal cornea for comparison. A three dimensional endoscopic confocal corneal "fly through" video was created with Analyze software version 7.0 (Biomedical Imaging Resource Mayo Clinic, Rochester, MN). Videos were analyzed and compared by two independent observers for evidence of keratocyte hypercellularity, inflammatory cells and changes to the overlying epithelium.
We demonstrate a novel technique for qualitative confocal analysis of a cornea with an AcuFocusTM corneal inlay. When compared to the control eye, the endoscopic confocal "fly through" videos demonstrated a well tolerated implant with lack of surrounding keratocyte hypercelluarlity, inflammatory cells or alteration to the overlying epithelium. This technique provides the unique ability to view the spatial relationship of the implant and surrounding cellular layers.
The three dimensional endoscopic confocal corneal "fly through" video is a novel and useful tool for qualitative analysis of the impact of the AcuFocusTM corneal inlay on corneal physiology. Although only a single eye was reported, confocal microscopy demonstrated that the AcuFocusTM corneal inlay appears well tolerated in the human cornea.
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