May 2008
Volume 49, Issue 13
ARVO Annual Meeting Abstract  |   May 2008
High Resolution Anterior Segment Spectral Optical Coherence Tomography for the Imaging of Subtle Alterationsi In the Corneal Structure in Real Time
Author Affiliations & Notes
  • A. Cervino
    Optics, University of Valencia, Burjassot, Spain
  • D. Bansal
    Optopol Technologies S.A., Zawiercie, Poland
  • R. Montes-Mico
    Optics, University of Valencia, Burjassot, Spain
  • J. J. Kaluzny
    Institute of Physics, Nicolaus Copernicus University, Torun, Poland
  • Footnotes
    Commercial Relationships  A. Cervino, None; D. Bansal, Commercial Interest in Anterius SOCT, E; R. Montes-Mico, None; J.J. Kaluzny, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2263. doi:
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      A. Cervino, D. Bansal, R. Montes-Mico, J. J. Kaluzny; High Resolution Anterior Segment Spectral Optical Coherence Tomography for the Imaging of Subtle Alterationsi In the Corneal Structure in Real Time. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2263.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To determine the clinical value of high resolution anterior segment spectral optical coherence tomography (SOCT Anterius, Optopol Technology S.A., Poland) for the in-vivo imaging and observation of subtle corneal structural alterations in real time.

Methods: : Four patients with different corneal conditions were examined with the new anterior segment spectral domain OCT: 4 years after penetrating keratoplasty, Fuchs dystrophy, post- refractive surgery for myopia (PRK) and advanced granular corneal dystrophy. The system uses a 870nm wavelength for high resolution high speed observation of anterior segment structures with an axial resolution of 3µm and lateral resolution of 7µm. It provides 25000 A-scans per second, with a scanning density of 3500 A-scans per mm.

Results: : Although there is a frame size limitation, imaging of small corneal segments, higher resolution allowed observation of structures showing levels of detail not achieved with previous anterior segment OCT devices available, allowing the determination of location and size of corneal structures, epithelial corneal thickness and even corneal transparency grading.

Conclusions: : Anterior segment SOCT Anterius provides information of high clinical value of subtle corneal dystrophies.In vivo measurement of epithelial thickness profile and obervation of subtle corneal alterations in real time expand the applications of SOCT for corneal imaging in both clinical and research settings

Keywords: cornea: clinical science • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical 

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