May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Association of Combined IL-13/IL-4R Signaling Pathway Gene Polymorphism With Stevens-Johnson Syndrome
Author Affiliations & Notes
  • M. Ueta
    Ophthalmology, Kyoto Prefectural Univ of Med, Kamigyo-Ku, Japan
  • C. Sotozono
    Ophthalmology, Kyoto Prefectural Univ of Med, Kamigyo-Ku, Japan
  • T. Inatomi
    Ophthalmology, Kyoto Prefectural Univ of Med, Kamigyo-Ku, Japan
  • J. Hamuro
    Ophthalmology, Kyoto Prefectural Univ of Med, Kamigyo-Ku, Japan
  • S. Kinoshita
    Ophthalmology, Kyoto Prefectural Univ of Med, Kamigyo-Ku, Japan
  • Footnotes
    Commercial Relationships  M. Ueta, None; C. Sotozono, None; T. Inatomi, None; J. Hamuro, None; S. Kinoshita, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2359. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      M. Ueta, C. Sotozono, T. Inatomi, J. Hamuro, S. Kinoshita; Association of Combined IL-13/IL-4R Signaling Pathway Gene Polymorphism With Stevens-Johnson Syndrome. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2359. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute-onset mucocutaneous diseases induced by infectious agents and/or inciting drugs. We previously reported that there is an association between SJS/TEN and IL-4R gene polymorphism which is essential for both IL-4 and IL-13 signaling. To examine IL-4 and IL-13 gene polymorphisms and the combination of these polymorphisms with IL-4R polymorphism, we performed polymorphism analysis.

Methods: : In 76 Japanese SJS/TEN patients with ocular surface complications and 160 healthy controls, we analyzed polymorphisms of the promoter -590C/T in the IL-4 gene, and of the promoter -1111C/T and Arg110Gln in the IL-13 gene and assessed Gln551Arg in the IL-4R gene. As Arg110Gln affects serum IL-13, plasma IL-13 levels were also examined.

Results: : In SJS/TEN, the Arg110Gln SNP of IL-13 were significantly associated and Arg110 alleles were increased significantly. Plasma IL-13 tended to be lower in SJS/TEN patients than the controls. Analysis of the genotype pattern of IL-4R SNP Gln551Arg and IL-13 SNP Arg110Gln showed that the Gln/Gln(A/A) - Arg/Arg(G/G) genotype pattern was strongly associated with SJS/TEN.

Conclusions: : IL-13 gene polymorphisms might be associated with SJS/TEN. Our findings suggest that SJS/TEN is different from allergic diseases such as atopy and asthma because the ratio of each allele in the IL-13 SNP Arg110Gln was the opposite of the ratio in atopy and asthma. They also reveal that combined polymorphisms in the IL-13/IL-4R signaling pathway were associated with SJS/TEN.

Keywords: conjunctivitis • inflammation • genetics 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×