May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Cytokine Profile in Human Corneal Inflammatory Disease
Author Affiliations & Notes
  • P. Hossain
    University of Southampton, Southampton, United Kingdom
    Southampton Eye Unit,
    Division of Infection, Inflammation & Repair,
  • F. Afshar
    Southampton Eye Unit, Southampton General Hospital, Southampton, United Kingdom
  • C. Webb
    University of Southampton, Southampton, United Kingdom
    Division of Infection, Inflammation & Repair,
  • S. L. Pender
    University of Southampton, Southampton, United Kingdom
    Division of Infection, Inflammation & Repair,
  • D. F. Anderson
    Southampton Eye Unit, Southampton General Hospital, Southampton, United Kingdom
  • Footnotes
    Commercial Relationships  P. Hossain, None; F. Afshar, None; C. Webb, None; S.L. Pender, None; D.F. Anderson, None.
  • Footnotes
    Support  Gift of Sight & TFC Frost Foundation
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2389. doi:https://doi.org/
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    • Get Citation

      P. Hossain, F. Afshar, C. Webb, S. L. Pender, D. F. Anderson; Cytokine Profile in Human Corneal Inflammatory Disease. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2389. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Cytokines play a central role in the pathogenesis of corneal inflammatory disease (CID). Despite our current knowledge, the profile of different cytokines in human CID is not clear. Our aim was to determine the cytokine levels in patients with CID.

Methods: : Tear samples were obtained from controls(n=5) and CID(n=8) patients. Controls were from a similar group & excluded on the basis of previous eye surgery, contact lens wear, blepharitis and use of eye drops. Simultaneous analysis of cytokine levels in collected tears were performed using multiplexed immunoassays. The mean levels of GM-CSF, IFN-γ, IL-1β, IL-2, IL-6, IL-8, IL-10, IL-12, and TNF-α were measured in both groups of patients.

Results: : Mean cytokine levels for control and ulcer patients are shown in Fig 1 & 2. There were significant increased levels (p<0.05) of IL-1β, IL-2, IL-6, IL-8 & GM-CSF in CID patients. There were also increases in TNF-α & IFN-γ, however, little change in IL-10.

Keywords: keratitis • cytokines/chemokines • inflammation 
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