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M. Javaheri, J. Chung, S. Louie, M. Torres, H. Volk, R. N. Khurana, R. Varma, the LALES Group; Interleukin-8 and C-Reactive Protein Levels in Bilateral, High-Risk Non-Exudative Age-Related Macular Degeneration: The Los Angeles Latino Eye Study (LALES). Invest. Ophthalmol. Vis. Sci. 2008;49(13):2457.
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To evaluate levels of Interleukin-8 (IL-8) and C-Reactive Protein (CRP) in participants with bilateral, high-risk non-exudative age related macular degeneration (ARMD) in a population-based sample of Latinos.
The data for this analysis is derived from the Los Angeles Latino Eye Study (LALES), a population-based prevalence study of eye disease in Latinos (primarily Mexican-Americans) age 40 and older. All participants had fundus photographs that were graded for ARMD characteristics using a modified Wisconsin Age-Related Maculopathy Grading System in addition to providing stored blood specimens that were analyzed for levels of IL-8 and CRP. A case control study was performed. Eligible cases (n=118) included those with bilateral soft indistinct drusen, indicating high-risk characteristics for progression of ARMD. Controls (n=118) were participants without any evidence of ARMD matched on age, body-mass index, sex, presence of hypertension, presence of cardiovascular disease and smoking status. Chi-square and Student’s t-tests were used to assess differences between cases and controls across various markers of inflammation. Logistic regression was conducted to determine the independant relationship between IL-8, CRP, and ARMD.
On univariate analysis, differences between the cases and the controls were present for CRP (p<0.001) and IL-8 (p<0.001). Mean CRP values were 2289.2 ng/mL for cases and 2089.8 ng/mL for controls. Mean IL-8 values were 1572.6 pg/mL for cases and 1065.6 pg/mL for controls. However, on logistic regression analyses, after controlling for diagnoses related to systemic inflammation, such as diabetes and history of arthritis, only IL-8 was significantly associated with bilateral soft indistinct drusen ARMD (p=0.04).
After matching participants on a variety of factors and controlling for markers of inflammation, our results suggest a significant increase in IL-8 in participants with bilateral, soft drusen, while CRP was not. These results may indicate a novel role for IL-8 as a systemic inflammatory marker in Latinos with high-risk non-exudative ARMD.
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