May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Interleukin-8 and C-Reactive Protein Levels in Bilateral, High-Risk Non-Exudative Age-Related Macular Degeneration: The Los Angeles Latino Eye Study (LALES)
M. Javaheri; J. Chung; S. Louie; M. Torres; H. Volk; R. N. Khurana; R. Varma; the LALES Group
Author Affiliations & Notes
  • M. Javaheri
    Doheny Eye Institue and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California
  • J. Chung
    Department of Preventative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
  • S. Louie
    School of Pharmacy, Keck School of Medicine, University of Southern California, Los Angeles, California
  • M. Torres
    Doheny Eye Institue and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California
  • H. Volk
    Department of Preventative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
  • R. N. Khurana
    Doheny Eye Institue and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California
  • R. Varma
    Doheny Eye Institue and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California
  • the LALES Group
    Doheny Eye Institue and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California
  • Footnotes
    Commercial Relationships  M. Javaheri, None; J. Chung, None; S. Louie, None; M. Torres, None; H. Volk, None; R.N. Khurana, None; R. Varma, None.
  • Footnotes
    Support  NIH Grants EY-11753, EY-03040, and unrestricted grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2457. doi:
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      M. Javaheri, J. Chung, S. Louie, M. Torres, H. Volk, R. N. Khurana, R. Varma, the LALES Group; Interleukin-8 and C-Reactive Protein Levels in Bilateral, High-Risk Non-Exudative Age-Related Macular Degeneration: The Los Angeles Latino Eye Study (LALES). Invest. Ophthalmol. Vis. Sci. 2008;49(13):2457.

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Abstract

Purpose: : To evaluate levels of Interleukin-8 (IL-8) and C-Reactive Protein (CRP) in participants with bilateral, high-risk non-exudative age related macular degeneration (ARMD) in a population-based sample of Latinos.

Methods: : The data for this analysis is derived from the Los Angeles Latino Eye Study (LALES), a population-based prevalence study of eye disease in Latinos (primarily Mexican-Americans) age 40 and older. All participants had fundus photographs that were graded for ARMD characteristics using a modified Wisconsin Age-Related Maculopathy Grading System in addition to providing stored blood specimens that were analyzed for levels of IL-8 and CRP. A case control study was performed. Eligible cases (n=118) included those with bilateral soft indistinct drusen, indicating high-risk characteristics for progression of ARMD. Controls (n=118) were participants without any evidence of ARMD matched on age, body-mass index, sex, presence of hypertension, presence of cardiovascular disease and smoking status. Chi-square and Student’s t-tests were used to assess differences between cases and controls across various markers of inflammation. Logistic regression was conducted to determine the independant relationship between IL-8, CRP, and ARMD.

Results: : On univariate analysis, differences between the cases and the controls were present for CRP (p<0.001) and IL-8 (p<0.001). Mean CRP values were 2289.2 ng/mL for cases and 2089.8 ng/mL for controls. Mean IL-8 values were 1572.6 pg/mL for cases and 1065.6 pg/mL for controls. However, on logistic regression analyses, after controlling for diagnoses related to systemic inflammation, such as diabetes and history of arthritis, only IL-8 was significantly associated with bilateral soft indistinct drusen ARMD (p=0.04).

Conclusions: : After matching participants on a variety of factors and controlling for markers of inflammation, our results suggest a significant increase in IL-8 in participants with bilateral, soft drusen, while CRP was not. These results may indicate a novel role for IL-8 as a systemic inflammatory marker in Latinos with high-risk non-exudative ARMD.

Keywords: age-related macular degeneration • cytokines/chemokines • clinical (human) or epidemiologic studies: prevalence/incidence 
© 2008, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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