May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Epidemic Keratoconjunctivitis Due to a Novel Hexon-Chimeric Intermediate HumanAdenovirus 22, 37/h8 in Japan
Author Affiliations & Notes
  • K. Aoki
    Dept of Ophth and Visual Sciences, Hokkaido Univ Grad School of Med, Sapporo-shi, Japan
  • H. Ishiko
    Advanced Medicine Research Department, Mitsubishi Chemical Medience, Tokyo, Japan
  • Y. Tagawa
    Dept of Ophth and Visual Sciences, Hokkaido Univ Grad School of Med, Sapporo-shi, Japan
  • T. Ohguchi
    Dept of Ophth and Visual Sciences, Hokkaido Univ Grad School of Med, Sapporo-shi, Japan
  • H. Kaneko
    Department of Microbiology, Fukushima Medical University School of Medicine, Fukushima-shi, Japan
  • S. Ohno
    Dept of Ophth and Visual Sciences, Hokkaido Univ Grad School of Med, Sapporo-shi, Japan
  • Footnotes
    Commercial Relationships  K. Aoki, None; H. Ishiko, None; Y. Tagawa, None; T. Ohguchi, None; H. Kaneko, None; S. Ohno, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2488. doi:https://doi.org/
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      K. Aoki, H. Ishiko, Y. Tagawa, T. Ohguchi, H. Kaneko, S. Ohno; Epidemic Keratoconjunctivitis Due to a Novel Hexon-Chimeric Intermediate HumanAdenovirus 22, 37/h8 in Japan. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2488. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To report a novel hexon-chimeric intermediate human adenovirus (HAdV) 22, 37/H8 in Japan.

Methods: : A total of 12 isolates were obtained from patients with epidemic keratoconjunctivitis (EKC) at four different hospitals during 2003-2007 in Japan. The isolates were identified as HAdV-8 or 37 previously. The nucleotide sequence of the full-length hexon and fiber genes of the isolates were determined, and were compared to those of 51 prototype strains.

Results: : 1. The restriction pattern of the viral genome of the all isolates showed a different restriction pattern from the HAdV-8,-19a and 37 prototype strains. 2. The sequence of the hexon (ε determinant) Loop-1 and -2 regions showed the highest nucleotide identity with HAdV-22. 3. The sequence of the hexon conserved region 4 was completely identical to that of HAdV-37. 4. However, the nucleotide sequence of the fiber knob was identical to that of HAdV-8 prototype strain.

Conclusions: : This virus is a new hexon-chimeric intermediate human adenovirus 22, 37/H8 and an etiological agent of EKC in Japan.

Keywords: adenovirus • conjunctivitis • inflammation 
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