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K. Aoki, H. Ishiko, Y. Tagawa, T. Ohguchi, H. Kaneko, S. Ohno; Epidemic Keratoconjunctivitis Due to a Novel Hexon-Chimeric Intermediate HumanAdenovirus 22, 37/h8 in Japan. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2488. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To report a novel hexon-chimeric intermediate human adenovirus (HAdV) 22, 37/H8 in Japan.
A total of 12 isolates were obtained from patients with epidemic keratoconjunctivitis (EKC) at four different hospitals during 2003-2007 in Japan. The isolates were identified as HAdV-8 or 37 previously. The nucleotide sequence of the full-length hexon and fiber genes of the isolates were determined, and were compared to those of 51 prototype strains.
1. The restriction pattern of the viral genome of the all isolates showed a different restriction pattern from the HAdV-8,-19a and 37 prototype strains. 2. The sequence of the hexon (ε determinant) Loop-1 and -2 regions showed the highest nucleotide identity with HAdV-22. 3. The sequence of the hexon conserved region 4 was completely identical to that of HAdV-37. 4. However, the nucleotide sequence of the fiber knob was identical to that of HAdV-8 prototype strain.
This virus is a new hexon-chimeric intermediate human adenovirus 22, 37/H8 and an etiological agent of EKC in Japan.
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