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Y. Tagawa, H. Ishiko, K. Aoki, T. Ohguchi, S. Ohno; A Novel Human Adenovirus Caused Nosocomial Infections of Epidemic Keratoconjunctivitis in Japan. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2489.
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© ARVO (1962-2015); The Authors (2016-present)
To report a novel human adenovirus (HAdV) caused nosocomial infections of epidemic keratoconjunctivitis (EKC) in Japan.
A total of 80 HAdVs were isolated from patients with EKC at 6 different hospitals in Japan. The partial hexon gene sequences of the isolates were determined and compared to those of prototype strains of 51 serotypes.
1. All isolates had an identical partial hexon nucleotide sequence. 2. The phylogenetic analysis classified these isolates in species of HAdV-D. 3. The isolates represented 93.9% to 95.1% nucleotide identities with HAdV-D prototype strains, whereas all 32 prototype strains in HAdV-D ranged from 93.2% to 99.2%. 4. The sequence of the Loop 2 region and fiber knob region from the representative strain was dissimilar from all prototype strains of 51 serotypes. 5. A quantitative neutralization assay and restriction cleavage pattern suggested that these strains were a novel serotype in the species HAdV-D
This virus is a novel serotype of human adenoviruses, which cause EKC in Japan.
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