May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
A Novel Human Adenovirus Caused Nosocomial Infections of Epidemic Keratoconjunctivitis in Japan
Author Affiliations & Notes
  • Y. Tagawa
    Dept of Ophthalmology, Hokkaido University Sch of Med, Sapporo-shi, Japan
  • H. Ishiko
    Advance Medicine Research Department, Mitsubishi Chemical Medience Corporation, Tokyo, Japan
  • K. Aoki
    Dept of Ophthalmology, Hokkaido University Sch of Med, Sapporo-shi, Japan
  • T. Ohguchi
    Dept of Ophthalmology, Hokkaido University Sch of Med, Sapporo-shi, Japan
  • S. Ohno
    Dept of Ophthalmology, Hokkaido University Sch of Med, Sapporo-shi, Japan
  • Footnotes
    Commercial Relationships  Y. Tagawa, None; H. Ishiko, None; K. Aoki, None; T. Ohguchi, None; S. Ohno, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2489. doi:https://doi.org/
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      Y. Tagawa, H. Ishiko, K. Aoki, T. Ohguchi, S. Ohno; A Novel Human Adenovirus Caused Nosocomial Infections of Epidemic Keratoconjunctivitis in Japan. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2489. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To report a novel human adenovirus (HAdV) caused nosocomial infections of epidemic keratoconjunctivitis (EKC) in Japan.

Methods: : A total of 80 HAdVs were isolated from patients with EKC at 6 different hospitals in Japan. The partial hexon gene sequences of the isolates were determined and compared to those of prototype strains of 51 serotypes.

Results: : 1. All isolates had an identical partial hexon nucleotide sequence. 2. The phylogenetic analysis classified these isolates in species of HAdV-D. 3. The isolates represented 93.9% to 95.1% nucleotide identities with HAdV-D prototype strains, whereas all 32 prototype strains in HAdV-D ranged from 93.2% to 99.2%. 4. The sequence of the Loop 2 region and fiber knob region from the representative strain was dissimilar from all prototype strains of 51 serotypes. 5. A quantitative neutralization assay and restriction cleavage pattern suggested that these strains were a novel serotype in the species HAdV-D

Conclusions: : This virus is a novel serotype of human adenoviruses, which cause EKC in Japan.

Keywords: adenovirus • conjunctivitis • inflammation 
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