May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
PD-1 Expression in the Development of Anterior Chamber-Associated Immune Deviation
Author Affiliations & Notes
  • Q. Meng
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China
  • P. Yang
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China
  • B. Li
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China
  • H. Zhou
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China
  • X. Huang
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China
  • Footnotes
    Commercial Relationships  Q. Meng, None; P. Yang, None; B. Li, None; H. Zhou, None; X. Huang, None.
  • Footnotes
    Support  Fund for the National Natural Science Foundation (30400487), Research Group Fund of Guangdong Province Natural Science (2005-04) and Innovation Research Groups of China
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2515. doi:https://doi.org/
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    • Get Citation

      Q. Meng, P. Yang, B. Li, H. Zhou, X. Huang; PD-1 Expression in the Development of Anterior Chamber-Associated Immune Deviation. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2515. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To study the expression and possible implication of programmed death-1 (PD-1) in iris-ciliary body from mice with anterior chamber-associated immune deviation (ACAID).

Methods: : ACAID was induced in BALB/c mice by the intracameral injection of 50µg ovalbumin (OVA) and evaluated by delayed-type hypersensitivity response. The expressions of PD-1 and its ligands in iris-ciliary bodies from ACAID mice were determined by fluorescent quantitative real-time polymerase chain reaction and immunohistochemistry.

Results: : Both mRNA and protein of PD-1 and PD-L1 were expressed in the iris-ciliary body. PD-1 mRNA and protein were up-regulated in ACAID mice, while PD-L1 mRNA and protein were up-regulated in positive control mice. Neither mRNA nor protein of PD-L2 was detected in the iris-ciliary body of the different groups.

Conclusions: : An increased expression of PD-1 in iris-ciliary body of ACAID mice indicates its involvement in the induction of this immune deviation.

Keywords: ACAID • inhibitory receptors • uvea 
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