May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
PD-1 Expression in the Development of Anterior Chamber-Associated Immune Deviation
Q. Meng; P. Yang; B. Li; H. Zhou; X. Huang
Author Affiliations & Notes
  • Q. Meng
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China
  • P. Yang
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China
  • B. Li
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China
  • H. Zhou
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China
  • X. Huang
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China
  • Footnotes
    Commercial Relationships  Q. Meng, None; P. Yang, None; B. Li, None; H. Zhou, None; X. Huang, None.
  • Footnotes
    Support  Fund for the National Natural Science Foundation (30400487), Research Group Fund of Guangdong Province Natural Science (2005-04) and Innovation Research Groups of China
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2515. doi:
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      Q. Meng, P. Yang, B. Li, H. Zhou, X. Huang; PD-1 Expression in the Development of Anterior Chamber-Associated Immune Deviation. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2515.

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Abstract

Purpose: : To study the expression and possible implication of programmed death-1 (PD-1) in iris-ciliary body from mice with anterior chamber-associated immune deviation (ACAID).

Methods: : ACAID was induced in BALB/c mice by the intracameral injection of 50µg ovalbumin (OVA) and evaluated by delayed-type hypersensitivity response. The expressions of PD-1 and its ligands in iris-ciliary bodies from ACAID mice were determined by fluorescent quantitative real-time polymerase chain reaction and immunohistochemistry.

Results: : Both mRNA and protein of PD-1 and PD-L1 were expressed in the iris-ciliary body. PD-1 mRNA and protein were up-regulated in ACAID mice, while PD-L1 mRNA and protein were up-regulated in positive control mice. Neither mRNA nor protein of PD-L2 was detected in the iris-ciliary body of the different groups.

Conclusions: : An increased expression of PD-1 in iris-ciliary body of ACAID mice indicates its involvement in the induction of this immune deviation.

Keywords: ACAID • inhibitory receptors • uvea 
© 2008, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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