May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Left Eye Predominance in Amblyopia
Author Affiliations & Notes
  • M. X. Repka
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • R. T. Kraker
    Jaeb Center for Health Research, Tampa, Florida
  • K. A. Simons
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • Pediatric Eye Disease Investigator Group
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • Footnotes
    Commercial Relationships  M.X. Repka, None; R.T. Kraker, None; K.A. Simons, None.
  • Footnotes
    Support  NIH Grant EY11751
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2589. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      M. X. Repka, R. T. Kraker, K. A. Simons, Pediatric Eye Disease Investigator Group; Left Eye Predominance in Amblyopia. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2589. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To report the prevalence of amblyopia in right or left eyes of children 3 to <18 years of age.

Methods: : The Pediatric Eye Disease Investigator Group has conducted 9 prospective randomized treatment trials of amblyopia in children between 3 and <18 years of age across North America. 2694 children were enrolled with visual acuity in the amblyopic eye, 20/40 to 20/400. We compared the proportion of right and left eyes affected by amblyopia and examined the influence of baseline and demographic factors on the distribution.

Results: : Overall, left eyes were more frequently affected by amblyopia than right eyes (56.6% vs 43.4%, p<0.001). This association was independent of age (p=0.46), race (p=0.28), and severity of amblyopic eye visual acuity (p=0.27), but was related to anisometropia as the underlying cause of amblyopia (p<0.001). Among patients with cause of amblyopia defined as anisometropia alone or combined mechanism (anisometropia and strabismus), left eyes were more frequently affected by amblyopia than right eyes (59.5% vs 40.5%, p<0.001). Among patients with cause of amblyopia defined as strabismus alone 50.3% were affected by amblyopia in the left eye compared to 49.7% in the right (p=0.89).

Conclusions: : Anisometropia (with or without strabismus) was strongly associated with the predominance of amblyopia in left eyes. Further study is needed to determine whether there are factors which predispose to the development of greater hypermetropia in left eyes.

Clinical Trial: : www.clinicaltrials.gov NCT00001864

Keywords: amblyopia • strabismus • refractive error development 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×