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P.-C. Wu, P.-C. Fang; Myopia Prevention With 0.025% Atropine Solution in Premyopia Children. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2601.
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To evaluate the efficacy of 0.025% atropine solution for prevention of myopia in premyopia children.
Retrospective case-control study.Fivety-two children (3-12 year-old) children with spherical refractive status range between +0.75 and -0.75D(which defined as premyopia), cylinder refractive status less than -2D, without amblyopia, who had received 0.025% atropine eyedrop once at night or no treatment after regular follow-up for one year at Chang Gung Memorial Hospital(Kaohsiung, Taiwan) from 2004 to 2007, were enrolled.
Twenty six children (average age 6.7 y/o) were in 0.025% atropine group and 26 children (average age 6.8 y/o) in control group. Mean spherical refraction progression in the 0.025% atropine group was -0.02 +/- 0.50 D/year, significantly lower than control group which was -0.69 +/- 0.46 D/year.(p<0.01)
Topical 0.025% atropine eyedrop administration at bedtime regularly has effect on prevention myopia onset in premyopic school-aged children for one year period.
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