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M. K. Tsilimbaris, T. D. Panagiotoglou, C. Tsika, V. Pandeleondidis, G. Kymionis; Intravitreal Injection of Ketorolac Tromethamine in Postoperative Cystoid Macular Edema. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2693.
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The aim of this pilot study is to investigate the effect of intravitreal administration of ketorolac tromethamine in post-operative cystoid macular edema.
5 patients diagnosed with post-operative cystoid macular edema were enrolled. 2 patients received 2 intravitreal injections of 300µg (0, 05 ml) of ketorolac tromethamine (Toradol), with a three-week interval, while 3 patients received 4 consecutive intravitreal injections of 500µg (0, 05 ml) weekly. Visual acuity assessment, tonometry, fundoscopy and optical coherence tomography (OCT) were performed prior to first injection and weekly for the following 5 weeks. Fluorescein angiography was performed before 1st injection and at 5th week period.
No adverse reactions were noticed in any patient. Analysis of data indicates a trend for improvement of visual acuity as well as regression of edema after initiation of therapy with rebound after week three in all patients.
This pilot study indicates a possible role of intravitreal injection of ketorolac tromethamine in patients with postoperative cystoid macular edema. Further research is warranted in order to obtain conclusive results concerning doses and timing of injections.
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