May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
A Randomized Placebo-Controlled Clinical Study of Lutein for Angiographic Macula Edema After Cataract Surgery
Author Affiliations & Notes
  • T. Ueda
    Ophthalmology, Showa Univ Sch of Medicine, Tokyo, Japan
  • R. Hiramatsu
    Ophthalmology, Showa Univ Sch of Medicine, Tokyo, Japan
  • E. Ogura
    Ophthalmology, Showa Univ Sch of Medicine, Tokyo, Japan
  • Y. Taguchi
    Ophthalmology, Showa Univ Sch of Medicine, Tokyo, Japan
  • S. Mizuno
    Jard Inc., Tokyo, Japan
  • R. Koide
    Ophthalmology, Showa Univ Sch of Medicine, Tokyo, Japan
  • Footnotes
    Commercial Relationships  T. Ueda, None; R. Hiramatsu, None; E. Ogura, None; Y. Taguchi, None; S. Mizuno, None; R. Koide, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2695. doi:https://doi.org/
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    • Get Citation

      T. Ueda, R. Hiramatsu, E. Ogura, Y. Taguchi, S. Mizuno, R. Koide; A Randomized Placebo-Controlled Clinical Study of Lutein for Angiographic Macula Edema After Cataract Surgery. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2695. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the effect of lutein treatment on the incidence of angiographic macula edema.

Methods: : A randomized placebo-controlled clinical study was performed. Fifty cataract patients with no indications of macular disease enrolled ranged in age from 48 to 84 years. The patients received placebo or lutein (10 mg once daily) from 1 month before cataract surgery till 6 months after the surgery. The angiographic macula edema was detected by fluorescence angiography (FA) at 3 and 6 months after the surgery. The cataract surgeries were carried out by one surgeon. The patients received the UV-filtering intra ocular lens.

Results: : The visual acuity of all of the patients were above 14/20 after the surgery. At 3 months after the surgery, the macula leakage by FA was observed 14%(3/22) patients in the lutein group and 42%(11/26) in placebo group, respectively. At 6 months, the macula leakage by FA decreased significantly from 36%(9/25) in the placebo group to 5%(1/22) (P<0.05).

Conclusions: : These results indicate that the lutein treatment decreased the incidence of angiographic macula edema or it may be effective in recovery of angiographic macula edema after cataract surgery.

Clinical Trial: : www.umin.ac.jp/ctr/index/htm UMIN000000938

Keywords: nutritional factors • macula/fovea 
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