May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Pars Plana Vitrectomy and Bevacizumab for Diffuse Diabetic Macular Edema (Pilot Study)
Author Affiliations & Notes
  • V. Kon-Jara
    Retina, Asociacion Para Evitar La Ceguera En Mexico, Mexico, Mexico
  • M. Martinez-Castellanos
    Retina, Asociacion Para Evitar La Ceguera En Mexico, Mexico, Mexico
  • O. Alvarez-Verduzco
    Retina, Asociacion Para Evitar La Ceguera En Mexico, Mexico, Mexico
  • J. Guerrero-Naranjo
    Retina, Asociacion Para Evitar La Ceguera En Mexico, Mexico, Mexico
  • M. Torres-Soriano
    Retina, Asociacion Para Evitar La Ceguera En Mexico, Mexico, Mexico
  • J. Diaz-Rubio
    Retina, Asociacion Para Evitar La Ceguera En Mexico, Mexico, Mexico
  • H. Quiroz-Mercado
    Retina, Asociacion Para Evitar La Ceguera En Mexico, Mexico, Mexico
  • Footnotes
    Commercial Relationships  V. Kon-Jara, None; M. Martinez-Castellanos, None; O. Alvarez-Verduzco, None; J. Guerrero-Naranjo, None; M. Torres-Soriano, None; J. Diaz-Rubio, None; H. Quiroz-Mercado, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2704. doi:https://doi.org/
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    • Get Citation

      V. Kon-Jara, M. Martinez-Castellanos, O. Alvarez-Verduzco, J. Guerrero-Naranjo, M. Torres-Soriano, J. Diaz-Rubio, H. Quiroz-Mercado; Pars Plana Vitrectomy and Bevacizumab for Diffuse Diabetic Macular Edema (Pilot Study). Invest. Ophthalmol. Vis. Sci. 2008;49(13):2704. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the combined effect of Bevacizumab and Pars plana vitrectomy to stabilize retinal thickness and visual acuity in diffuse diabetic macular edema. (pilot study)

Methods: : Prospective, randomized, longitudinal study. We recruited patients with diagnosis of diabetes mellitus type 2, older than 25 yo, with diffuse diabetic macular edema with or withour prior treatment, without subfoveal exudates. A complete ophthalmological evaluation was done, and outcome measures were best corrected visual acuity (BCVA) by ETDRS and retinal thickness by optical coherence tomography at baseline, one month and third month. All patients underwent pars plana vitrectomy and bevacizumab injection (2.5 mg/0.1ml). There were 2 groups, group 1: Patients without renal disease. Group 2: Patients with renal disease.

Results: : We studied 10 patients every single group. Both groups showed improvement in BCVA and decreased retinal thickness, however, in diabetic nephropathy patients their improvement were less evident. P was not statistically significant.

Conclusions: : Combined therapy of Vitrectomy and Bevacizumab could be a safe and effective treatment to control diffuse diabetic macular edema even without evidence of macular traction at three month follow-up, but further studies are necessary to determine long-term efficacy.

Clinical Trial: : www.clinicaltrials.gov APEC-ret

Keywords: macula/fovea • edema • diabetic retinopathy 
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