Abstract
Purpose: :
The"VItrectomy for Diabetic macular Edema" (VIDE) Study has the purpose to estabilish the role of vitrectomy in changing the natural course of diffuse non tractional diabetic macular edema.
Methods: :
In this phase II multicentric prospective clinical trial we have analized 37 eyes of 32 patients with chronic non tractional cystoid diabetic macular edema who underwent pars plana vitrectomy associated (75%) or not with peeling of internal limiting membrane. Patients were followed for 28 to 60 months, with a mean follow-up of 38.5 months. Main outcomes were visual acuity measured by Snellen chart and central retinal thickness and retinal volume measured by Optical Coherence Tomography.
Results: :
Mean visual acuity improved from 0,22 preoperatively to 0,34 at the end of follow-up. Visual acuity remained unchanged in 52% of the patients, decreased of 2 or more lines in 12%, improved of 2 or more lines in 36% and of 4-6 lines in 16%. Mean central retinal thickness measured by OCT decreased from 413 µ preoperatively to 291 µ postoperatively, with an improvement in 84% of the eyes and absence of edema at the end of follow-up in 44%. Macular volume decreased from 9,81 mm3 to 8,81 mm3, with an improvement in 60% of the eyes and absence of edema at the end of follow-up in 24%.
Conclusions: :
Vitrectomy for diabetic macular edema is a procedure still under investigation but these data demonstrate that may be effective in reducing non tractional diabetic macular edema in the long term.
Keywords: vitreoretinal surgery • diabetic retinopathy • vitreous