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G. Bertoldo, E. Gusson, G. Panozzo; Vitrectomy for Diabetic Macular Edema: Long Term Results. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2715. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
The"VItrectomy for Diabetic macular Edema" (VIDE) Study has the purpose to estabilish the role of vitrectomy in changing the natural course of diffuse non tractional diabetic macular edema.
In this phase II multicentric prospective clinical trial we have analized 37 eyes of 32 patients with chronic non tractional cystoid diabetic macular edema who underwent pars plana vitrectomy associated (75%) or not with peeling of internal limiting membrane. Patients were followed for 28 to 60 months, with a mean follow-up of 38.5 months. Main outcomes were visual acuity measured by Snellen chart and central retinal thickness and retinal volume measured by Optical Coherence Tomography.
Mean visual acuity improved from 0,22 preoperatively to 0,34 at the end of follow-up. Visual acuity remained unchanged in 52% of the patients, decreased of 2 or more lines in 12%, improved of 2 or more lines in 36% and of 4-6 lines in 16%. Mean central retinal thickness measured by OCT decreased from 413 µ preoperatively to 291 µ postoperatively, with an improvement in 84% of the eyes and absence of edema at the end of follow-up in 44%. Macular volume decreased from 9,81 mm3 to 8,81 mm3, with an improvement in 60% of the eyes and absence of edema at the end of follow-up in 24%.
Vitrectomy for diabetic macular edema is a procedure still under investigation but these data demonstrate that may be effective in reducing non tractional diabetic macular edema in the long term.
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