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A. M. Minnella, B. Falsini, A. Scupola, P. Sasso, L. Ziccardi, G. Stifano, L. Montrone, D. Marangoni, A. Mastrocola, E. Balestrazzi; Short-Term Functional Results After Intravitreal Bevacizumab (AvastinTM) for Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2716. doi: https://doi.org/.
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To assess the short-term effects of intravitreal bevacizumab injection on retinal function by focal electoretinogram (fERG) and microperimetry (MP1).
Twenty-one patients with exudative age related-macular degeneration (AMD) were treated with 0.125 mg/ml of intravitreal bevacizumab and evaluated, before and after injection, by best spectacle corrected visual acuity (BSCVA), fERGs to 8 Hz and 41 Hz flicker stimulation (central 18 degrees), MP1 sensitivity (central 10 degrees) and fixation stability. During 1-month follow-up, none of the patients underwent re-injection and the following parameters were considered: BSCVA, fERG 8 Hz 1st and 2nd harmonic response amplitude and 41 Hz 1st harmonic, MP1 sensitivity and 2° and 4° fixation stabillity.
When compared to baseline values, BSCVA, MP1 sensitivity and fixation stability improved (p < 0.001) at the end of study. No significant changes were observed for any of the FERG parameters. Significant positive correlations (r = 0.56; p < 0.01) were observed between microperimetry parameters and BSCVA at 30 days after injection.
Results suggest an improvement of central retinal function following intravitreal bevacizumab for AMD.
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