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T. M. Dzhusoev, Y. V. Bayborodov, Jr.; Avastine Injections Into Sub-tenon’s Space Prior to Surgical Treatment for Diabetic Proliferative Retinopathy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2729.
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To study effects of sub-Tenon’s injections of Avastive on course of neoangiogenesis and ability of Avastine to cause detachment of posterior hyaloid in complex surgical treatment of patients with diabetic proliferative retinopathy.
Twenty-eight eyes of fourteen patients diagnosed with type I diabetes mellitus and diabetic proliferative retinopathy in both eyes, underwent eye surgical treatment. Seven days prior to the surgery all patients received injection of Avastine, 5 mg, into sub-Tenon’s space. Surgical treatment included vitrectomy with posterior hyaloid membrane (PHM) removal. Pre- and post-operative methods of evaluation included fundoscopy, B-scanning, optical coherent tomography (OCT) and photography.
Significant regress of new vessels on PHM was observed within pre-operative week following Avastine injection in all patients. One week after the injection, fundoscopy, B-scan, OCT and photography revealed enlargement of macular edema area in patients with attached macula and increased retinal detachment height along with partial PHM detachment in patients with detached macula.Intra-operative bleeding during PHM peeling was avoided in 13 out of 14 patients.
Sub-Tenon’s injection of 5 mg Avastine one week prior to surgical treatment in patients with diabetic proliferative retinopathy results in significant regress of vitreoretinal neovascularization and induces PHM detachment.
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