May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Dyslipidemia: Is It a Factor in Retinal Ischemia in Diabetes?
Author Affiliations & Notes
  • G. Wu
    Ophthalmology, Stanford Univ School of Medicine, Stanford, California
  • G. Tso
    University of California at Berkeley, Berkeley, California
  • F. Yu
    Medicine, Qiqihar Medical University, Qiqihar, China
  • Q. Nguyen
    Biology, University of California, Irvine, Irvine, California
  • M. Severns
    Ophthalmology, LKC Technologies, Gaithersburg, Maryland
  • Footnotes
    Commercial Relationships  G. Wu, None; G. Tso, None; F. Yu, None; Q. Nguyen, None; M. Severns, LKC Technologies, E.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2733. doi:https://doi.org/
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    • Get Citation

      G. Wu, G. Tso, F. Yu, Q. Nguyen, M. Severns; Dyslipidemia: Is It a Factor in Retinal Ischemia in Diabetes?. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2733. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To use the 30 Hz flicker electroretinogram (ERG) to compare retinal function in diabetic patients (DP) and non-diabetic patients (NDP) with elevated lipid levels.

Methods: : Lipid profiles, fasting blood sugars, were collected. The diabetic patients' HbA1c were collected, as well. All patients had a Snellen visual acuity eligibility range of 20/20-20/40. The diabetic patients (DP) were age matched with non-diabetic patients (NDP). NDP Photopic 30 Hz flicker were recorded according to the ISCEV standard protocol using Epic 4000 system (LKC Technologies). Eyes were dilated and a DTL electrode was used for recording. Implicit time (IT) and amplitude (AMP) of the ERG were measured by placing cursors on the waveform.

Results: : 20 patients were included in the study. 10 DP and 10 NDP. The age range of the DP=39-86yrs, avg 67.9yrs +13.9 ; NDP=39-81yrs, avg 67.6yrs +11.8. Lipid levels were: Cholesterol (CH) avg: DP=169.1mg/dl +50.65, NDP=178.1mg/dl +37.7 (p=ns); Triglycerides (TG) avg: DP=109.3mg/dl +41.9, NDP= 85.2mg/dl +38.68(p≤0.05); Low density lipoprotein (LDL) avg: DP= 91.8 mg/dl +37.5, NDP=96.3 mg/dl +27.9 (p=ns); High density lipoprotein (HDL) avg: DP=52.7 mg/dl +14.4, NDP=63.8 mg/dl +23.4 (p≤ 0.03). For age matched group, there were 9 DP (18 eyes) and 9 NDP (18 eyes) : DP AMP range=46.9 - 118.2 uV; avg=75.94 uV + 19.09, NDP AMP=range 52.1 - 166.5 uV; avg =100.10 uV + 35.70 (p≤0.016, t-test), DP IT range=26.2 - 36.6 msec; avg=29.80 msec + 3.72, NDP IT range=26.3 - 35.7 msec; avg =29.03 msec + 3.11 (p=ns, t-test). Using chi square analysis of the age matched DP and NDP: in patients with elevated TG ≥ 100 mg/dl and implicit times≥ 32 msec or below, the implicit times were increased in DP vs. NDP(p≤0.05, chi square). In patients with elevated cholesterol ≥150 and implicit times ≥ 32 msec or below, DP had a greater delay in implicit time than NDP(p≤ 0.05, chi square). For DP, using regression analysis, Implicit time vs. LDL was significant(p≤0.036).

Keywords: diabetic retinopathy • electroretinography: clinical • lipids 
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