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K. Klemp, M. La Cour; The Effect of Acetazolamide on the Multifocal Electroretinogram and Retinal Vessel Diameter in Diabetic Patients. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2759.
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To examine the effect of acetazolamide on the human multifocal electroretinogram and the retinal vessel diameter in diabetic patients.
MfERGs and fundus photos were recorded in 5 eyes of 5 diabetic patients before and 60 min after intravenous administration of 500 mg acetazolamide. MfERGs were recorded using the Veris 5 system. An array of 61 hexagons was displayed at a frame rate of 75 Hz and 3 dark frames were inserted between each m-sequence step. Retinal vessel diameters were measured from fundus photographs using a digital technique. The study followed the tenets of the Declaration of Helsinki.
The carbonic anhydrase inhibitor acetazolamide reduced mean retinal vessel diameter by 3.2% and increased mean mfERG amplitudes by 5.3% in diabetic patients.
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