May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
The Effect of Acetazolamide on the Multifocal Electroretinogram and Retinal Vessel Diameter in Diabetic Patients
Author Affiliations & Notes
  • K. Klemp
    Ophthalmology, Univ of Copenhagen Glostrup Hospital, Glostrup, Denmark
  • M. La Cour
    Ophthalmology, Univ of Copenhagen Glostrup Hospital, Glostrup, Denmark
  • Footnotes
    Commercial Relationships  K. Klemp, None; M. La Cour, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2759. doi:
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    • Get Citation

      K. Klemp, M. La Cour; The Effect of Acetazolamide on the Multifocal Electroretinogram and Retinal Vessel Diameter in Diabetic Patients. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2759.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To examine the effect of acetazolamide on the human multifocal electroretinogram and the retinal vessel diameter in diabetic patients.

Methods: : MfERGs and fundus photos were recorded in 5 eyes of 5 diabetic patients before and 60 min after intravenous administration of 500 mg acetazolamide. MfERGs were recorded using the Veris 5 system. An array of 61 hexagons was displayed at a frame rate of 75 Hz and 3 dark frames were inserted between each m-sequence step. Retinal vessel diameters were measured from fundus photographs using a digital technique. The study followed the tenets of the Declaration of Helsinki.

Results: : The carbonic anhydrase inhibitor acetazolamide reduced mean retinal vessel diameter by 3.2% and increased mean mfERG amplitudes by 5.3% in diabetic patients.

Keywords: carbonic anhydrase • diabetes • electrophysiology: non-clinical 
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