May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Correlation Between OCT Spectral Imaging and Microperimetry Evaluation in Diabetic Macular Edema Treated With Bevacizumab
Author Affiliations & Notes
  • F. Contini
    Department of Ophthalmology, Insubria University, Varese, Italy
  • S. Donati
    Department of Ophthalmology, Insubria University, Varese, Italy
  • P. Chelazzi
    Department of Ophthalmology, Insubria University, Varese, Italy
  • M. Bianchi
    Department of Ophthalmology, Insubria University, Varese, Italy
  • C. Azzolini
    Department of Ophthalmology, Insubria University, Varese, Italy
  • Footnotes
    Commercial Relationships  F. Contini, None; S. Donati, None; P. Chelazzi, None; M. Bianchi, None; C. Azzolini, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2762. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      F. Contini, S. Donati, P. Chelazzi, M. Bianchi, C. Azzolini; Correlation Between OCT Spectral Imaging and Microperimetry Evaluation in Diabetic Macular Edema Treated With Bevacizumab. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2762. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : to compare visual acuity variation, retina sensitivity and macular fixation related to diabetic macular edema OCT patterns in patients treated with intravitreal bevacizumabMaterials and

Methods: : 20 eyes of 15 patients affected by persistent diabetic macular edema were included in this study (mean follow up 5.3 months). A complete ophthalmological examination was performed before the treatment and at 1-2-3 months after the bevacizumab injection, completed by fluorescin angiography, OCT/SLO OTI and MP1 NIDEK microperimetry evaluation. We classified OCT macular edema patterns in 3 Groups: sponge like (Group 1) cystoid (Group 2), serous foveal detachment (Group 3) as reported in literature.

Results: : OCT examination identified before the treatment 7 eyes on Group 1, 7 eyes on Group 2, 6 eyes on Group 3; at 3 months post treatment 12 eyes on Group 1, 6 eyes on Group 2, 2 eyes on Group 3. In all patients mean visual acuity was 0.32 on pretreatment evaluation and 0.63 at 3 months after the bevacizumab injection. Pretreatment mean retinal sensitivity was 7.2 dB and at 3 months post treatment 9.6 dB. Data analysis on each specified Group showed a significative correlation factor on Group 1 and 2 between retinal sensitivity and VA improvement on pretreatment and 3 months post-treatment evaluation.

Conclusions: : our study showed the correlation between post treatment visual acuity improvement and retinal-photoreceptor preservation, measured with functional macular parameters. Retinal sensitivity represents a predictive factor to assess the efficacy of the treatment, more than a simple evidence of OCT retinal thinning.

Keywords: vascular endothelial growth factor • diabetic retinopathy • perimetry 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×