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F. Contini, S. Donati, P. Chelazzi, M. Bianchi, C. Azzolini; Correlation Between OCT Spectral Imaging and Microperimetry Evaluation in Diabetic Macular Edema Treated With Bevacizumab. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2762.
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to compare visual acuity variation, retina sensitivity and macular fixation related to diabetic macular edema OCT patterns in patients treated with intravitreal bevacizumabMaterials and
20 eyes of 15 patients affected by persistent diabetic macular edema were included in this study (mean follow up 5.3 months). A complete ophthalmological examination was performed before the treatment and at 1-2-3 months after the bevacizumab injection, completed by fluorescin angiography, OCT/SLO OTI and MP1 NIDEK microperimetry evaluation. We classified OCT macular edema patterns in 3 Groups: sponge like (Group 1) cystoid (Group 2), serous foveal detachment (Group 3) as reported in literature.
OCT examination identified before the treatment 7 eyes on Group 1, 7 eyes on Group 2, 6 eyes on Group 3; at 3 months post treatment 12 eyes on Group 1, 6 eyes on Group 2, 2 eyes on Group 3. In all patients mean visual acuity was 0.32 on pretreatment evaluation and 0.63 at 3 months after the bevacizumab injection. Pretreatment mean retinal sensitivity was 7.2 dB and at 3 months post treatment 9.6 dB. Data analysis on each specified Group showed a significative correlation factor on Group 1 and 2 between retinal sensitivity and VA improvement on pretreatment and 3 months post-treatment evaluation.
our study showed the correlation between post treatment visual acuity improvement and retinal-photoreceptor preservation, measured with functional macular parameters. Retinal sensitivity represents a predictive factor to assess the efficacy of the treatment, more than a simple evidence of OCT retinal thinning.
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