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T. Tsumura, H. Takahashi, K. Kashiwagi, H. Iijima; Comparison of Central Corneal Thickness Measurements Using Anterior Segment Oct, Specular Microscope, and Scanning Peripheral Anterior Chamber Depth Analyzer. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2802. doi: https://doi.org/.
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The aim of this study was to compare central corneal thickness (CCT) measurement by three non-contact devices, the specular microscope, Anterior Segment Optical Coherent Tomography (AS-OCT), and Scanning Peripheral Anterior Chamber Depth Analyzer (SPAC).
This study was a prospective, cross-sectional study of 43 eyes from 43 adult subjects without corneal disorder resulting difficulty in measurement. There were 20 male subjects and 23 female subjects with mean age of 34.1±8.0 yrs. CCT of right eyes in all subjects was measured using a specular microscope (FA-3509, Konan Medical, Japan), AS-OCT (Carl Zeiss Meditec, Dublin, CA), and SPAC (Takagi, Japan). One examiner measured three time of each subject with an examiner-masked fashion and mean CCT values were employed for analysis.
The mean CCT was 541.0±30.9 µm with a specular microscope, 524.5±27.6 µm with AS-OCT, and 532.0±25.4 µm with SPAC, respectively. There was no significant difference in CCT values among the three devices. The correlations between AS-OCT and SPAC, AS-OCT and specular microscope, or SPAC and specular microscope were 0.876, 0.946 and 0.918, respectively.
Specular microscope measurements of CCT are slightly thicker than those of AS-OCT and SPAC. However, as the differences found are small, they are unlikely to be clinically important.
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