May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Reproducibility of Tear Meniscus Measurement by Fourier Domain Optical Coherence Tomography
Author Affiliations & Notes
  • S. Zhou
    Doheny Eye Institute, Los Angeles, California
    Department of Ophthalmology,
    Department of Cornea and Refractive Surgery, Zhong Shan Ophthalmic Center, Sun Yat-Sen University, Guang Zhou, China
  • Y. Li
    Doheny Eye Institute, Los Angeles, California
    Department of Ophthalmology,
  • P. Liu
    Doheny Eye Institute, Los Angeles, California
    Department of Ophthalmology,
    College of Biomedical Engineering & Instrument Science, Zhe Jiang University, Hang Zhou, China
  • S. C. Yiu
    Doheny Eye Institute, Los Angeles, California
    Department of ophthalmology,
  • D. Huang
    Doheny Eye Institute, Los Angeles, California
    Department of Ophthalmology,
  • Footnotes
    Commercial Relationships  S. Zhou, None; Y. Li, Optovue, Inc., F; Optovue, Inc., P; P. Liu, None; S.C. Yiu, None; D. Huang, Optovue, Inc., F; Optovue, Inc., I; Optovue, Inc., C; Optovue, Inc., P; Optovue, Inc., R.
  • Footnotes
    Support  NIH grants R01 EY018184-01, P30 EY03040; Research to Prevent Blindness; Optovue, Inc; CHINA SCHOLARSHIP 2007U25183
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 2803. doi:https://doi.org/
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    • Get Citation

      S. Zhou, Y. Li, P. Liu, S. C. Yiu, D. Huang; Reproducibility of Tear Meniscus Measurement by Fourier Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2803. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To study the reproducibility of tear meniscus measurement withhigh-speed high-resolution Fourier-domain optical coherencetomography (FD-OCT).

 
Methods:
 

The lower tear meniscus (TM) was imaged by vertical scans centeredon the inferior cornea and the lower eye lid using an FD-OCTsystem (RTVue, Optovue Inc., Fremont, CA) with a corneal adaptormodule (CAM) in the right eyes of 20 normal subjects. The systemperforms 26,000 axial scans per second and has a 5-micron axialresolution.Each subject was examined at 2 visits at least onemonth apart. Each eye was scanned twice on each visit. The scanswere taken 2 seconds after a blink.The TM angle (α), height (TMH)and depth (TMD) were measured (Figure) with a computer caliper.The TM area was calculated by the formula 0.5 × height × depth,based on a triangular approximation.

 
Results:
 

Fair to good intervisit reproducibility was demonstrated bythe intraclass correlation (ICC), pooled standard deviation(SD) and coefficient of correlation (CV) (Table).

 
Conclusions:
 

Lower tear meniscus dimensions and angle can be measured byFD-OCT with fair to good intervisit reproducibility. The heightwas the most repeatable meniscus dimension. FD-OCT may be auseful way to measure dry eye severity and treatment effectiveness.  

 

 
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical • cornea: tears/tear film/dry eye 
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