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S. Zhou, Y. Li, P. Liu, S. C. Yiu, D. Huang; Reproducibility of Tear Meniscus Measurement by Fourier Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2008;49(13):2803.
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To study the reproducibility of tear meniscus measurement withhigh-speed high-resolution Fourier-domain optical coherencetomography (FD-OCT).
The lower tear meniscus (TM) was imaged by vertical scans centeredon the inferior cornea and the lower eye lid using an FD-OCTsystem (RTVue, Optovue Inc., Fremont, CA) with a corneal adaptormodule (CAM) in the right eyes of 20 normal subjects. The systemperforms 26,000 axial scans per second and has a 5-micron axialresolution.Each subject was examined at 2 visits at least onemonth apart. Each eye was scanned twice on each visit. The scanswere taken 2 seconds after a blink.The TM angle (α), height (TMH)and depth (TMD) were measured (Figure) with a computer caliper.The TM area was calculated by the formula 0.5 × height × depth,based on a triangular approximation.
Fair to good intervisit reproducibility was demonstrated bythe intraclass correlation (ICC), pooled standard deviation(SD) and coefficient of correlation (CV) (Table).
Lower tear meniscus dimensions and angle can be measured byFD-OCT with fair to good intervisit reproducibility. The heightwas the most repeatable meniscus dimension. FD-OCT may be auseful way to measure dry eye severity and treatment effectiveness.
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