May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Safe Implantation of a Flexible Electrode Array Into the Eye by ‘Sandwich’ Technique
Author Affiliations & Notes
  • J.-M. Seo
    School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
  • C. Dodds
    Biomedical Engineering, University of New South Wales, Sydney, Australia
  • Y. T. Wong
    Biomedical Engineering, University of New South Wales, Sydney, Australia
  • E. Kim
    School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
  • J. Zhou
    School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
  • J. W. Morley
    School of Medicine, University of Western Sydney, Penrith, NSW, Australia
  • G. J. Suaning
    Biomedical Engineering, University of New South Wales, Sydney, Australia
  • N. H. Lovell
    Biomedical Engineering, University of New South Wales, Sydney, Australia
  • S. Kim
    School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
  • H. Chung
    Nano Artificial Vision Research Center, Nano Bioelectronics & System Research Center, Seoul, Republic of Korea
    Ophthalmology, Seoul National University School of Medicine, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  J. Seo, None; C. Dodds, None; Y.T. Wong, None; E. Kim, None; J. Zhou, None; J.W. Morley, None; G.J. Suaning, None; N.H. Lovell, None; S. Kim, None; H. Chung, None.
  • Footnotes
    Support  Korea Health 21 R&D Project MOHW A050251, NBS-ERC supported by KOSEF, NH&MRC, ARC and Retina Australia
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3038. doi:
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      J.-M. Seo, C. Dodds, Y. T. Wong, E. Kim, J. Zhou, J. W. Morley, G. J. Suaning, N. H. Lovell, S. Kim, H. Chung; Safe Implantation of a Flexible Electrode Array Into the Eye by ‘Sandwich’ Technique. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3038.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To implant a silicone-based platinum multi-electrode array into the subretinal or suprachoroidal space without folding, a dual guide ‘sandwich’ technique has been developed.

Methods: : A fourteen-channel platinum multi-electrode array was fabricated by silicone spin coating followed by micromachining of Pt tracks and electrodes using an Nd:YAG laser beam at 1064 nm. The thickness of the electrode array was approximately 75 µm and thus very soft and flexible. A polyimide guide was fabricated with the same shape as the silicone electrode array, except for a rounded triangular shape on the tip. A New Zealand white rabbit was used for an in vivo experiment. Two polyimide guides were coated with viscoelastic on both sides and the silicone electrode was placed between the two. A scleral tunnel was made 4 mm posterior from the corneal limbus and the ‘sandwiched’ silicone electrode was implanted through the scleral tunnel under the subretinal or into the suprachoroidal space. After identifying the position of the electrode array, each polyimide guide was removed, one at a time and the silicone electrode was kept in situ for further experimentation.

Results: : By the proposed method, a silicone-based multi-electrode array could be properly positioned without folding, and the placement verified by optical coherent tomography. Electrically evoked potentials recorded at the visual cortex showed that the ‘sandwich’ method was suitable for in vivo electrophysiological experimentation.

Conclusions: : The ‘sandwich’ technique is a suitable method to implant thin, flexible multi-electrode arrays into eyes for artificial retinal systems.

Keywords: retina • transplantation 
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