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J.-M. Seo, C. Dodds, Y. T. Wong, E. Kim, J. Zhou, J. W. Morley, G. J. Suaning, N. H. Lovell, S. Kim, H. Chung; Safe Implantation of a Flexible Electrode Array Into the Eye by ‘Sandwich’ Technique. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3038.
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© ARVO (1962-2015); The Authors (2016-present)
To implant a silicone-based platinum multi-electrode array into the subretinal or suprachoroidal space without folding, a dual guide ‘sandwich’ technique has been developed.
A fourteen-channel platinum multi-electrode array was fabricated by silicone spin coating followed by micromachining of Pt tracks and electrodes using an Nd:YAG laser beam at 1064 nm. The thickness of the electrode array was approximately 75 µm and thus very soft and flexible. A polyimide guide was fabricated with the same shape as the silicone electrode array, except for a rounded triangular shape on the tip. A New Zealand white rabbit was used for an in vivo experiment. Two polyimide guides were coated with viscoelastic on both sides and the silicone electrode was placed between the two. A scleral tunnel was made 4 mm posterior from the corneal limbus and the ‘sandwiched’ silicone electrode was implanted through the scleral tunnel under the subretinal or into the suprachoroidal space. After identifying the position of the electrode array, each polyimide guide was removed, one at a time and the silicone electrode was kept in situ for further experimentation.
By the proposed method, a silicone-based multi-electrode array could be properly positioned without folding, and the placement verified by optical coherent tomography. Electrically evoked potentials recorded at the visual cortex showed that the ‘sandwich’ method was suitable for in vivo electrophysiological experimentation.
The ‘sandwich’ technique is a suitable method to implant thin, flexible multi-electrode arrays into eyes for artificial retinal systems.
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