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M. A. Zapata, J. E. Fernandez, J. Nieto, J. Farrando, C. Macia, A. Boixadera, A. Fonollosa, V. J. Martinez-Castillo, J. Garcia-Arumi; Reproducibility of Fovea, Foveal Minimum and Macular Volume Measurements Using Optical Coherence Tomography in Normal Eyes, Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3220.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the reliability of fovea, foveal minimum and macular volume measurements using optical coherence tomography in normal, neovascular age-related macular degeneration (NAMD) and eyes with diabetic macular edema (DME).
Prospective instrument validation study. Ten normal subjects were compared with 10 age-related macular degeneration patients and 10 diabetic patients. Five repetitions of a series of scans on five separate occasions within a 5 minutes period were performed. Each eye was scanned at Fast Macular Thickness map, using a Retinal Thickness Tabular for data analysis (Zeiss OCT3 system). Quality criteria for scans were: an accurately localization of inner limiting membrane and retinal pigment epithelium surface, signal strength over 5 (maximum 10), and no low confidence analysis. Patients were asked to fixate at the center of the green fixation dot, in cases that subject cannot see the green fixation target the operator adjusted the position of scans to best coincide with the location of the center of the macula. Outcomes were analyzed with intraclass correlation coefficients (ICCs) using repeated measures regression. The ICC was used as a measure of reliability.
Intraobserver reliability was good for all three measures, fovea 0.944 (0,908-0,970), Foveal Minimum 0.919 (0,868-0,956) and Macular Volume 0.980 (0,966-0,989). Healthy patients showed worse intraobserver reproducibility of all three measures [fovea 0.717 (0,473-0,904), Foveal Minimum 0.503 (0,223-0,803), Macula Volume 0.939 (0,858-0,982)], NAMD group outcomes were Fovea 0.938 (0,856-0,982), Foveal Minimum 0.890 (0,759-0,967) and Macular Volume 0.961 (0,908-0,989). ICC were better in the DME group Fovea 0.943 (0,866-0,983), Foveal Minimun 0.939 (0,859-0,982) and Macular Volume 0.984 (0,960-0,995). Results were statistically significative.
Intraobserver reliability is good for all three measures. In eyes were fixation capability has been damaged reliability is better, maybe because the exam depends only of the operator. Foveal minimum has lower confidence intraobserver, and Total Macular Volume is the meassure with better intraobserver reliability.
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