May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Simultaneous Confocal Scanning Laser Ophthalmoscopy and High Resolution Optical Coherence Tomography in Type 2 Idiopathic Macular Telangiectasia
Author Affiliations & Notes
  • H.-M. Helb
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • P. Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • H. P. N. Scholl
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • F. G. Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Footnotes
    Commercial Relationships  H. Helb, None; P. Charbel Issa, None; H.P.N. Scholl, None; F.G. Holz, Heidelberg Engineering, F; Zeiss Meditec, F; Heidelberg Engineering, C; Zeiss Meditec, C.
  • Footnotes
    Support  Supported by The Lowy Medical Research Institute (The Macular Telangiectasia Project), DFG Heisenberg fellowship SCHO 734/2-1; EU FP6, Integrated Project "EVI-GENORET" (LSHG-CT-2005-512036)
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3275. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      H.-M. Helb, P. Charbel Issa, H. P. N. Scholl, F. G. Holz; Simultaneous Confocal Scanning Laser Ophthalmoscopy and High Resolution Optical Coherence Tomography in Type 2 Idiopathic Macular Telangiectasia. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3275. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To analyze findings derived from combined imaging using confocal scanning laser ophthalmoscopy (cSLO) and high resolution spectral domain optical coherence tomography (SD-OCT) in patients with type 2 idiopathic macular telangiectasia (type 2 IMT).

Methods: : Eighteen eyes of 9 patients with type 2 IMT were examined. cSLO and SD-OCT images were recorded simultaneously (Spectralis HRA+OCT, Heidelberg Engineering, Germany). The cSLO was used in different imaging modes including fluorescein angiography (FLA), infrared and redfree reflectance as well as fundus autofluorescence (FAF). Conventional time domain (TD) OCT was also performed.

Results: : Assessment of en face views of three dimensional volume scans revealed hyporeflective spaces that were arranged parafoveally in a petaloid pattern. Usually, there were multiple small spaces separated from each other. Overlays of the late phase FLA with hyporeflective spaces identified on en face images revealed that there was no or only minimal leakage into the hyporeflective spaces. In one patient with an increased foveal signal in FLA imaging, SD-OCT scan revealed a layer of increased reflectance between the retinal pigment epithelial layer and the outer neurosensory retina that was not detectable by TD-OCT. This abnormality suggests accumulation of autofluorescent material.Parafoveally, SD-OCT scans showed an increased signal of the inner neurosensory retina. The area of increased reflectance was correlated with the area of leakage on FLA. The border between the layers in that area showed a ragged outline. An area of decreased confocal infrared reflectance was frequently observed. Such areas were correlated with disruption of the junction between the inner and outer segments of the photoreceptors. In a subset of patients, loss of outer neurosensory layers including the photoreceptors was observed in SD-OCT imaging.

Conclusions: : Combined cSLO and SD-OCT imaging provides unprecedented in vivo details of the pathology in type 2-IMT. It unequivocally reveals the three-dimensional structure of features previously observed by TD-OCT such as hyporeflective retinal spaces and their behaviour in FLA. It proves to be a useful tool for elucidating disease pathogenesis and may be particularly helpful for longitudinal assessment and monitoring of therapeutic interventions in type 2 IMT.

Keywords: imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • macula/fovea 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×