May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Spectral Transmission of Clear and Yellow pHEMA IOL Pre-Post 6 Months Implantation in Rabbits
Author Affiliations & Notes
  • N. M. Pumariega
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine, Miami, Florida
    Biomedical Optics Laboratory, Dept. of Biomedical Engineering, Univ. of Miami College of Engineering, Coral Gables, Florida
  • E. Arrieta-Quintero
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine, Miami, Florida
  • A. Amelinckx
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine, Miami, Florida
  • I. Nose
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine, Miami, Florida
  • W. Lee
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine, Miami, Florida
  • D. Borja
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine, Miami, Florida
    Biomedical Optics Laboratory, Dept. of Biomedical Engineering, Univ. of Miami College of Engineering, Coral Gables, Florida
  • F. Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine, Miami, Florida
    Biomedical Optics Laboratory, Dept. of Biomedical Engineering, Univ. of Miami College of Engineering, Coral Gables, Florida
  • M. Aguilar
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine, Miami, Florida
    Biomedical Optics Laboratory, Dept. of Biomedical Engineering, Univ. of Miami College of Engineering, Coral Gables, Florida
  • J.-M. Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine, Miami, Florida
    University of Liege, Ophthalmology, CHU Sart-Tillman, Liege, Belgium
  • Footnotes
    Commercial Relationships  N.M. Pumariega, None; E. Arrieta-Quintero, None; A. Amelinckx, None; I. Nose, None; W. Lee, None; D. Borja, None; F. Manns, None; M. Aguilar, None; J. Parel, F, F.
  • Footnotes
    Support  Florida Lions Eye Bank; Croma-Pharma GmbH; NIH Center Grant P30-EY014801; Research to Prevent Blindness; Henri and Flore Lesieur Foundation (JMP)
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3345. doi:https://doi.org/
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      N. M. Pumariega, E. Arrieta-Quintero, A. Amelinckx, I. Nose, W. Lee, D. Borja, F. Manns, M. Aguilar, J.-M. Parel; Spectral Transmission of Clear and Yellow pHEMA IOL Pre-Post 6 Months Implantation in Rabbits. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3345. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare the spectral stability and biocompatibility of yellow and clear IOLs.

Methods: : A 300-600 nm portable testing system was designed using a fiber optic spectrometer (#SM240, Spectral Products-CVI, Putnam, CT) and a deep blue-white LED source with diffuser, iris diaphragm, voltage regulator and a transparent table supporting a sterile BSS filled Petri dish to hold the sample. Sterile IOLs of both types underwent spectral analyses. The study adhered to the ARVO Statement for the use of animals in research and followed ISO/DIS 11979-5 and approved institutional animal care guidelines. 12 NZW rabbits were implanted with IOLs having the same physical dimensions; 6 received a clear and 6 a yellow pHEMA IOL (Quatrix, 20D, Croma-Pharma, Austria) and underwent weekly ophthalmic exams for 6 months. Following euthanasia, a ring conforming to the anterior sclera was bonded with cyanoacrylate to the enucleated globe which was sectioned leaving an intact rim containing the lens or IOL in the capsular bag, zonules, ciliary body, anterior vitreous, hyaloid membrane, and sclera. The tissue sections underwent Miyake and shadowphotography exams and spectral transmission measurements. The IOLs were explanted and additional spectral measurements carried out. All tissues underwent histology.

Results: : Surgery and follow-up were uneventful. As with Acrysof and other IOLs (Fujiwara et al, ARVO IOVS 2001;42(4):S285 & 2001;42(4):S285) all eyes had PCO at 1 month. Both IOLs were equally biocompatible. No clinical and histology differences could be found between the 2 groups. Miyake and shadowphotography at 6 months showed de novo lens fibers in all eyes reducing transmission and impacting the spectra compared to the crystalline lens of unoperated contralateral eyes. There were no significant differences between the spectra of explanted and control IOLs.

Keywords: intraocular lens • optical properties 
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