May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Effect of Topical Beta-Blocker Eye Drops on Corneal Haze Formation After Photorefractive Keratectomy (prk): An Experimental Study
Author Affiliations & Notes
  • G. D. Kymionis
    Dept of Opthalmology, Inst of Vision, University of Crete, Heraklion, Greece
  • T. Ide
    Bascom Palmer Eye Institute, University of Miami, Florida
  • V. Diakonis
    Dept of Opthalmology, Inst of Vision, University of Crete, Heraklion, Greece
  • G. Kontadakis
    Dept of Opthalmology, Inst of Vision, University of Crete, Heraklion, Greece
  • M. Gretselos
    Dept of Opthalmology, Inst of Vision, University of Crete, Heraklion, Greece
  • D. Portaliou
    Dept of Opthalmology, Inst of Vision, University of Crete, Heraklion, Greece
  • S. Yoo
    Bascom Palmer Eye Institute, University of Miami, Florida
  • T. O'Brien
    Bascom Palmer Eye Institute, University of Miami, Florida
  • I. Pallikaris
    Dept of Opthalmology, Inst of Vision, University of Crete, Heraklion, Greece
  • Footnotes
    Commercial Relationships  G.D. Kymionis, None; T. Ide, None; V. Diakonis, None; G. Kontadakis, None; M. Gretselos, None; D. Portaliou, None; S. Yoo, None; T. O'Brien, None; I. Pallikaris, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3350. doi:https://doi.org/
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      G. D. Kymionis, T. Ide, V. Diakonis, G. Kontadakis, M. Gretselos, D. Portaliou, S. Yoo, T. O'Brien, I. Pallikaris; Effect of Topical Beta-Blocker Eye Drops on Corneal Haze Formation After Photorefractive Keratectomy (prk): An Experimental Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3350. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Carteolol hydrochloride inhibited gel contraction significantly while keratocytes treated by carteolol hydrochloride reduced collagen type III mRNA production in vitro model (human keratocytes). The purpose of this study is to investigate the effects of the application of topical carteolol hydrochloride (eye drops) after photorefractive keratectomy (PRK) on haze formation in an experimental model.

Methods: : Sixteen eyes of eight rabbits underwent PRK for -6 diopters (D) in a 6 mm optical zone. Four right eyes received carteolol hydrochloride 4 times a day for a month (study group), 4 right eyes received mitomycin C (0.02%) for two minutes intraoperatively while eight left eyes treated with balanced salt solution (BSS) 4 times daily for a month (control group). Slit lamp examination for haze formation (Fantes’ classification) was performed at the first and third postoperative month while corneal confocal microscopy was performed at the third postoperative month.

Results: : At the first and the third postoperative month evaluation, a decrease of haze formation in the study group (cartolol eye drops) in comparison with control group (BSS) was found while there was no haze formation in MMC treated group. Respectively, confocal microscopy analysis showed no haze formation or activated keratocytes in anterior stromal in MMC-group while there was haze formation and activated keratocytes in the anterior stroma in both control (BSS) and study (carteolol) groups (less prominent in the carteolol group).

Conclusions: : Carteolol hydrochloride could reduce haze formation after PRK. Further studies are needed in order to confirm these results

Keywords: refractive surgery • refractive surgery: complications • refractive surgery: PRK 
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