May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Endothelial Cell Density Following Surface Ablations for Moderate and High Myopia
J. M. Burka; K. S. Bower; D. A. Sediq; J. D. Edwards; R. D. Stutzman; R. C. VanRoekel; C. P. Kuzmowych; R. S. Howard
Author Affiliations & Notes
  • J. M. Burka
    Ophthalmology, Washington Hospital Center/Georgetown University, Washington, Dist. of Columbia
  • K. S. Bower
    Center for Refractive Surgery,
    Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • D. A. Sediq
    Center for Refractive Surgery,
    Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • J. D. Edwards
    Center for Refractive Surgery,
    Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • R. D. Stutzman
    Center for Refractive Surgery,
    Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • R. C. VanRoekel
    Optometry,
    Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • C. P. Kuzmowych
    Center for Refractive Surgery,
    Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • R. S. Howard
    Department of Clinical Investigation,
    Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • Footnotes
    Commercial Relationships  J.M. Burka, None; K.S. Bower, None; D.A. Sediq, None; J.D. Edwards, None; R.D. Stutzman, None; R.C. VanRoekel, None; C.P. Kuzmowych, None; R.S. Howard, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3355. doi:
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      J. M. Burka, K. S. Bower, D. A. Sediq, J. D. Edwards, R. D. Stutzman, R. C. VanRoekel, C. P. Kuzmowych, R. S. Howard; Endothelial Cell Density Following Surface Ablations for Moderate and High Myopia. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3355.

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Abstract

Purpose: : To compare changes in corneal endothelial cell counts after 3 types of surface ablations, photorefractive keratectomy (PRK), PRK with mitomycin C (MMC), and laser assisted subepithelial keratomileusis (LASEK).

Methods: : Active Duty Army soldiers, age 21 or over with stable myopia between -4.00D and -10.00D manifest spherical equivalent (MSE) were randomized to treatment of their dominant eye with either MMC-PRK (0.1 mg/ml x 1 minute) or LASEK. The fellow eye received conventional PRK. All procedures were performed using the LADARVision 4000 with Jupiter 2 software version 5.11. Endothelial cell counts were measured both preoperatively and at 6 and 12 months postoperatively with the Nikon Confoscan.

Results: : 193 subjects (97 PRK, 42 PRK with MMC and 54 LASEK) with follow-up at 6 months and 138 (69 PRK, 29 PRK with MMC and 40 LASEK) with follow-up at 12 months were analyzed for this report. For the PRK group there was found to me a median loss of 37 cells/mm2 (range: -1092 to 633) at 6 months post-operatively and 94 cells/mm2 (range: -682 to 890) at 12 months. This change was statistically significant at 12 months (p=0.001). For the PRK with MMC group there was a median loss of 55 cells/mm2 (range: -574 to 672) at 6 months and 35 cells/mm2 (range: -605 to 882) at 12 months, neither of which was statistically significant (p=0.344 and 0.429 respectively). Additionally, there was no significant change for the LASEK group with a median loss of 17 cells/mm2 (range: -936 to 543) at 6 months and a median gain of 37 cells/mm2 (range: -789 to 791) at 12 months (p=0.911 and 0.259 respectively). There was a significant difference between the 3 groups at 12 months with p=0.021. This difference was found to be primarily between the PRK and LASEK groups with p=0.004.

Conclusions: : There is a significant decrease in endothelial cell counts following PRK, however, PRK with MMC and LASEK appear to have no effect.

Keywords: refractive surgery: PRK • cornea: endothelium • refractive surgery: comparative studies 
© 2008, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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