May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Endothelial Cell Density Following Surface Ablations for Moderate and High Myopia
Author Affiliations & Notes
  • J. M. Burka
    Ophthalmology, Washington Hospital Center/Georgetown University, Washington, Dist. of Columbia
  • K. S. Bower
    Center for Refractive Surgery,
    Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • D. A. Sediq
    Center for Refractive Surgery,
    Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • J. D. Edwards
    Center for Refractive Surgery,
    Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • R. D. Stutzman
    Center for Refractive Surgery,
    Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • R. C. VanRoekel
    Optometry,
    Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • C. P. Kuzmowych
    Center for Refractive Surgery,
    Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • R. S. Howard
    Department of Clinical Investigation,
    Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • Footnotes
    Commercial Relationships  J.M. Burka, None; K.S. Bower, None; D.A. Sediq, None; J.D. Edwards, None; R.D. Stutzman, None; R.C. VanRoekel, None; C.P. Kuzmowych, None; R.S. Howard, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3355. doi:https://doi.org/
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      J. M. Burka, K. S. Bower, D. A. Sediq, J. D. Edwards, R. D. Stutzman, R. C. VanRoekel, C. P. Kuzmowych, R. S. Howard; Endothelial Cell Density Following Surface Ablations for Moderate and High Myopia. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3355. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare changes in corneal endothelial cell counts after 3 types of surface ablations, photorefractive keratectomy (PRK), PRK with mitomycin C (MMC), and laser assisted subepithelial keratomileusis (LASEK).

Methods: : Active Duty Army soldiers, age 21 or over with stable myopia between -4.00D and -10.00D manifest spherical equivalent (MSE) were randomized to treatment of their dominant eye with either MMC-PRK (0.1 mg/ml x 1 minute) or LASEK. The fellow eye received conventional PRK. All procedures were performed using the LADARVision 4000 with Jupiter 2 software version 5.11. Endothelial cell counts were measured both preoperatively and at 6 and 12 months postoperatively with the Nikon Confoscan.

Results: : 193 subjects (97 PRK, 42 PRK with MMC and 54 LASEK) with follow-up at 6 months and 138 (69 PRK, 29 PRK with MMC and 40 LASEK) with follow-up at 12 months were analyzed for this report. For the PRK group there was found to me a median loss of 37 cells/mm2 (range: -1092 to 633) at 6 months post-operatively and 94 cells/mm2 (range: -682 to 890) at 12 months. This change was statistically significant at 12 months (p=0.001). For the PRK with MMC group there was a median loss of 55 cells/mm2 (range: -574 to 672) at 6 months and 35 cells/mm2 (range: -605 to 882) at 12 months, neither of which was statistically significant (p=0.344 and 0.429 respectively). Additionally, there was no significant change for the LASEK group with a median loss of 17 cells/mm2 (range: -936 to 543) at 6 months and a median gain of 37 cells/mm2 (range: -789 to 791) at 12 months (p=0.911 and 0.259 respectively). There was a significant difference between the 3 groups at 12 months with p=0.021. This difference was found to be primarily between the PRK and LASEK groups with p=0.004.

Conclusions: : There is a significant decrease in endothelial cell counts following PRK, however, PRK with MMC and LASEK appear to have no effect.

Keywords: refractive surgery: PRK • cornea: endothelium • refractive surgery: comparative studies 
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