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J.-C. Gavrilov, B. Ameline-Chalumeau, M.-A. Chatel, M. Sellam, T. Gaujoux, V. M. Borderie, L. Laroche; Anterior Segment Optical Coherence Tomography Analysis of the Peripheral Corneal Response After Laser in situ Keratomileusis. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3366. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
The aim of this study was to analyse the modification of corneal peripheral thickness after laser in situ keratomileusis and to compare the results with the theoretical biomechanical response of the cornea.
Twenty eyes have been included in this prospective study. All patients underwent myopic treatment by LASIK with the same laser. Corneal central thickness (CCT) and corneal peripheral thickness (CPT) were measured with anterior segment optical coherence tomography (Visante OCT, Carl Zeiss Meditec), preoperatively and 3 months afterwards. Corneal peripheral thickness was measured 400 µm outside the flap, nasally and temporally. Peripheral thickness measurements were obtained from the high-resolution images.
Mean preoperative spherical equivalent was - 4.3 Diopters (D) ± 1.1 (SD). Preoperative CCT was 539.6 µm ± 32.7. Nasal CPT increased from 715.1 µm ± 46.6 preoperatively to 731.6 µm ± 44.9 at 3 months (P<.0001). Temporal CPT increased from 700.3 µm ± 47.1 to 721 µm ± 47.5 (P<.0001). Peripheral thickening of the stroma was greater temporally than nasally (20.7 µm ± 13.8 versus 16.55 µm ± 8.8 respectively). At three months postop the measured decrease in CCT was lower than the predicted one (respectively 56.6 µm versus 68.38 µm, P<.001).
Corneal peripheral thickness can be mesured with Visante OCT. An increase of the CPT was observed 3 months after LASIK. Results are in accordance with models of biomechanical response to LASIK. The expansion of the peripheral stroma seems to be due to the ablation of corneal lamellae. The difference between the modification in CCT measured at 3 months or calculated from the theoretical ablation can be the results of epithelial hyperplasia.
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