May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
In vivo Confocal Microscopic Study of Corneal Wound Healing Process After Corneal Epithelial Debridement in Diabetic Patients Who Recieved Pars Plana Vitrectomy
Author Affiliations & Notes
  • F.-R. Hu
    Ophthalmology Dept, National Taiwan Univ Hospital, Taipei, Taiwan
  • W.-L. Chen
    Ophthalmology Dept, National Taiwan Univ Hospital, Taipei, Taiwan
  • C.-M. Yang
    Ophthalmology Dept, National Taiwan Univ Hospital, Taipei, Taiwan
  • Footnotes
    Commercial Relationships  F. Hu, None; W. Chen, None; C. Yang, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 3399. doi:https://doi.org/
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      F.-R. Hu, W.-L. Chen, C.-M. Yang; In vivo Confocal Microscopic Study of Corneal Wound Healing Process After Corneal Epithelial Debridement in Diabetic Patients Who Recieved Pars Plana Vitrectomy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):3399. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To study the corneal epithelial wound healing process by in vivo confocal microscopy in diabetic patiensts who recevied corneal debridement during pars planal vitrectomy

Methods: : Forty eyes of 40 patients which recevied corneal debridement during pars planal vitrectomy for the treatment of proliferative retinopathy were enrolled. In vivo confocal microscopy was used to study the corneal epithelial wound healing process at post operative 1 week, 2 week, 1 month, 3 months and six months. The corneal basal and apical surface epithelial morphology were examined. Slit lamp biomicrscopy was also used to evaluate the corneal condition at the same time.

Results: : By slit lmap biomicroscopy, 75% of eyes were found to have completed corneal epitehlial wound healing within 2 weeks, and 90% were within 1 month. However, in vivo confocal microscopy demonstrated the wound healing process persisted to at least 3 months after operation in 82.5% of eyes. The delayed corneal epithelial wound healing process involved the late maturation of both corneal basal epithelial cells and apical cells.

Conclusions: : Corneal epithelial wound healing process in diabetic eyes is slow. Both corneal basal epithelial layer and apical layer are involved in the delayed wound healing process.

Clinical Trial: : www.clinicaltrials.gov 200702038R1

Keywords: cornea: clinical science • cornea: epithelium • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials 
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